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CAS 87-65-0

2,6-Dichlorophenol

Codes: (V)91353-7-a, (IV)91353-8-a, (IV)91353-9-a, (V)91353-10-a, (IV)91353-11-a

Application context (from source-drug indications)

Back painDiclofenac Sodium/Eperisone HydrochlorideOsteoarthritisDiclofenac SodiumRheumatoid arthritisDiclofenac SodiumAnkylosing spondylitisDiclofenac SodiumCommon bile duct diseaseDiclofenac SodiumDental pulp diseaseDiclofenac SodiumArthritisDiclofenac Sodium

Source drugs (routes using this intermediate)

DrugTierExpiry
Diclofenac Sodium/Eperisone HydrochlorideTier C — Watch / trade-
Diclofenac SodiumTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Diclofenac Sodium/Eperisone HydrochlorideOptimised routesteps: 6total yield: /
2-Phenylacetic acid methyl ester→Methyl (2-nitrophenyl)acetate→Methyl (2-aminophenyl)acetate→Methyl (2-benzamidophenyl)acetate→2,6-Dichlorophenol→Methyl (2-[(E)-[(2,6-dichlorophenoxy)(phenyl)methylidene]amino]phenyl)acetate→Methyl [2-[benzoyl(2,6-dichlorophenyl)amino]phenyl]acetate
Diclofenac Sodium/Eperisone HydrochlorideOptimised routesteps: 3total yield: /
(2-Aminophenyl)acetic acid→Methyl (2-aminophenyl)acetate→Methyl [2-(2-bromopropanamido)phenyl]acetate→2,6-Dichlorophenol→2-[2-(2,6-Dichlorophenylamino)phenyl]acetic acid
Diclofenac Sodium/Eperisone HydrochlorideOptimised routesteps: 5total yield: /
Aminobenzene→2-Chloranylethanoyl chloride→2-Chloro-N-phenylacetamide→2,6-Dichlorophenol→2,6-Dichloro-N-phenylphenylamine→2-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide→1-(2,6-Dichlorophenyl)-2,3-dihydro-1H-indol-2-one
Diclofenac Sodium/Eperisone HydrochlorideOptimised routesteps: 4total yield: /
2-Phenylacetic acid methyl ester→Methyl (2-nitrophenyl)acetate→Methyl (2-aminophenyl)acetate→3,5-Dichloro-4-hydroxybenzoic acid→2,6-Dichlorophenol→2-Chloroacetic acid ethyl ester→Ethyl (2,6-dichlorophenoxy)acetate→2-Chloranylethanoyl chloride
Diclofenac Sodium/Eperisone HydrochlorideOptimised routesteps: 6total yield: /
Aminobenzene→2-Chloroacetic acid→2-Chloro-N-phenylacetamide→2,6-Dichlorophenol→2-(2,6-Dichlorophenoxy)-N-phenylacetamide→N-(2,6-Dichlorophenyl)-2-hydroxy-N-phenylacetamide→2-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide→1-(2,6-Dichlorophenyl)-2,3-dihydro-1H-indol-2-one
Diclofenac SodiumOptimised routesteps: 6total yield: /
2-Phenylacetic acid methyl ester→Methyl (2-nitrophenyl)acetate→Methyl (2-aminophenyl)acetate→Methyl (2-benzamidophenyl)acetate→2,6-Dichlorophenol→Methyl (2-[(E)-[(2,6-dichlorophenoxy)(phenyl)methylidene]amino]phenyl)acetate→Methyl [2-[benzoyl(2,6-dichlorophenyl)amino]phenyl]acetate
Diclofenac SodiumOptimised routesteps: 3total yield: /
(2-Aminophenyl)acetic acid→Methyl (2-aminophenyl)acetate→Methyl [2-(2-bromopropanamido)phenyl]acetate→2,6-Dichlorophenol→2-[2-(2,6-Dichlorophenylamino)phenyl]acetic acid
Diclofenac SodiumOptimised routesteps: 5total yield: /
Aminobenzene→2-Chloranylethanoyl chloride→2-Chloro-N-phenylacetamide→2,6-Dichlorophenol→2,6-Dichloro-N-phenylphenylamine→2-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide→1-(2,6-Dichlorophenyl)-2,3-dihydro-1H-indol-2-one
Diclofenac SodiumOptimised routesteps: 4total yield: /
2-Phenylacetic acid methyl ester→Methyl (2-nitrophenyl)acetate→Methyl (2-aminophenyl)acetate→3,5-Dichloro-4-hydroxybenzoic acid→2,6-Dichlorophenol→2-Chloroacetic acid ethyl ester→Ethyl (2,6-dichlorophenoxy)acetate→2-Chloranylethanoyl chloride
Diclofenac SodiumOptimised routesteps: 6total yield: /
Aminobenzene→2-Chloroacetic acid→2-Chloro-N-phenylacetamide→2,6-Dichlorophenol→2-(2,6-Dichlorophenoxy)-N-phenylacetamide→N-(2,6-Dichlorophenyl)-2-hydroxy-N-phenylacetamide→2-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide→1-(2,6-Dichlorophenyl)-2,3-dihydro-1H-indol-2-one

Intermediates available on this site

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