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CAS 87-69-4
(2R,3R)-2,3-dihydroxysuccinic acid
Codes: ESKE-002, VINF-002, EPTI-054, NELF-028
Application context (from source-drug indications)
Major depressive disorderEsketamine HydrochlorideSuicidal ideationEsketamine HydrochlorideDepressive disorderEsketamine HydrochlorideAnaesthesiaEsketamine HydrochlorideTreatment-resistant depressionEsketamine HydrochloridePainEsketamine HydrochlorideUrinary tract neoplasmVinflunine DitartrateUrothelial carcinomaVinflunine DitartrateBreast cancerVinflunine DitartrateLung cancerVinflunine DitartrateGastric cancerVinflunine DitartratePenile cancerVinflunine DitartrateUnstable anginaEptifibatideMyocardial infarctionEptifibatideIschaemic strokeEptifibatideAcute coronary syndromeEptifibatideSickle cell diseaseEptifibatideST段抬高型心肌梗死EptifibatideHIV infectionNelfinavir MesylateMyelofibrosisNelfinavir Mesylate子宫颈功能不全Nelfinavir MesylateSystemic lupus erythematosusNelfinavir MesylateNon-small cell lung cancerNelfinavir Mesylate巨细胞病毒性视网膜炎Nelfinavir Mesylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Esketamine Hydrochloride | Tier B — Position early | 2029 |
| Vinflunine Ditartrate | Tier C — Watch / trade | - |
| Eptifibatide | Tier C — Watch / trade | - |
| Nelfinavir Mesylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
N-(((9H-fluoren-9-yl)methoxy)carbonyl)-S-trityl-L-cysteine→(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(tert-butoxy)-4-oxobutanoic acid→3-(tritylthio)propanoic acid→(S)-pyrrolidine-2-carboxylic acid→(S)-tert-butyl 3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(((S)-1-((S)-2-(((R)-1-amino-1-oxo-3-(tritylthio)propan-2-yl)carbamoyl)pyrrolidin-1-yl)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-4-oxobutanoate→L-cysteine hydrochloride→(R)-(9H-fluoren-9-yl)methyl (1-amino-1-oxo-3-(tritylthio)propan-2-yl)carbamate→(2R,3R)-2,3-dihydroxysuccinic acid→(R)-2-amino-3-(tritylthio)propanamide (2R,3R)-2,3-dihydroxysuccinate→(R)-1-((S)-2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(tert-butoxy)-4-oxobutanamido)-3-(1H-indol-3-yl)propanoyl)pyrrolidine-2-carboxylic acid→EPTI-057→EPTI-058→(S)-2-amino-3-(1H-indol-3-yl)propanoic acid→(S)-2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3-yl)propanoic acid→3-bromoprop-1-ene→(R)-2-allyl 1-tert-butyl pyrrolidine-1,2-dicarboxylate→(R)-allyl 1-((S)-2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3-yl)propanoyl)pyrrolidine-2-carboxylate→(R)-allyl 1-((S)-2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(tert-butoxy)-4-oxobutanamido)-3-(1H-indol-3-yl)propanoyl)pyrrolidine-2-carboxylate→EPTI-065→EPTI-066→EPTI-067
(3S,4aS,8aS)-N-(tert-butyl)decahydroisoquinoline-3-carboxamide→(3S,4aS,8aS)-N-(tert-butyl)-2-((R)-2-hydroxy-2-((S)-2-(3-hydroxy-2-methylphenyl)-4,5-dihydrooxazol-4-yl)ethyl)decahydroisoquinoline-3-carboxamide→(2R,3R)-2,3-dihydroxysuccinic acid→(4S,5S)-dimethyl 2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate→((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)dimethanol→((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(methylene) bis(4-methylbenzenesulfonate)→(2S,3S)-2,3-dihydroxybutane-1,4-diyl bis(4-methylbenzenesulfonate)→((4R,5R)-2-oxido-1,3,2-dioxathiolane-4,5-diyl)bis(methylene) bis(4-methylbenzenesulfonate)→((4R,5R)-2,2-dioxido-1,3,2-dioxathiolane-4,5-diyl)bis(methylene) bis(4-methylbenzenesulfonate)→sodium (2S,3S)-3-azido-1,4-bis(tosyloxy)butan-2-yl sulfate→(2S,3S)-2-azido-3-hydroxybutane-1,4-diyl bis(4-methylbenzenesulfonate)→(2S,3S)-3-hydroxy-1,4-bis(tosyloxy)butan-2-aminium chloride→3-(chlorocarbonyl)-2-methylphenyl acetate→3-((S)-4-((S)-1-hydroxy-2-(tosyloxy)ethyl)-4,5-dihydrooxazol-2-yl)-2-methylphenyl acetate
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