← Back to patent-cliff list
CAS 870-46-2
(tert-Butoxycarbonyl)hydrazinetert-butyl hydrazinecarboxylate
Codes: (III)461018-9-a, ATAZ-005
Application context (from source-drug indications)
Waldenström macroglobulinaemiaIbrutinibChronic lymphocytic leukaemiaIbrutinibMantle cell lymphomaIbrutinibGraft-versus-host diseaseIbrutinibHIV infectionAtazanavir Sulfate/CobicistatHIV infectionAtazanavir SulfateAcquired immunodeficiency syndromeAtazanavir SulfateMycobacterium tuberculosis infectionAtazanavir SulfateType 1 diabetesAtazanavir Sulfate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ibrutinib | Tier A — Act now | 2027 |
| Atazanavir Sulfate/Cobicistat | Tier C — Watch / trade | - |
| Atazanavir Sulfate | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Pyrimidine-4-carbonitrile→6-Chloropyrimidine-4-carbonitrile→(tert-Butoxycarbonyl)hydrazine→6-Hydrazinylpyrimidine-4-carbonitrile hydrogen chloride→(Chloromethyl)acetyl chloride→3-Bromopropanoyl chloride→3-Bromopropanoyl bromide→4-Phenoxybenzaldehyde→3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→N-Boc-3(S)-chloropiperidine→(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-3-chloropropan-1-one→1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-3-bromopropan-1-one
4-bromobenzaldehyde→1-bromo-4-(dimethoxymethyl)benzene→2-bromopyridine→4-(pyridin-2-yl)benzaldehyde→tert-butyl hydrazinecarboxylate→tert-butyl (E)-2-(4-(pyridin-2-yl)benzylidene)hydrazine-1-carboxylate→tert-butyl 2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→tert-butyl ((S)-1-((R)-oxiran-2-yl)-2-phenylethyl)carbamate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→(2S,3S)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol→(S)-2-((methoxycarbonyl)amino)-3,3-dimethylbutanoic acid
2-bromopyridine→4-(pyridin-2-yl)benzaldehyde→tert-butyl hydrazinecarboxylate→tert-butyl (E)-2-(4-(pyridin-2-yl)benzylidene)hydrazine-1-carboxylate→tert-butyl 2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→tert-butyl ((S)-1-((R)-oxiran-2-yl)-2-phenylethyl)carbamate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→(2S,3S)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol→(S)-2-((methoxycarbonyl)amino)-3,3-dimethylbutanoic acid→(4-formylphenyl)boronic acid→tert-butyl ((2S,3R)-3,4-dihydroxy-1-phenylbutan-2-yl)carbamate→(6R,7S)-7-benzyl-2,2,3,3,11,11-hexamethyl-9-oxo-4,10-dioxa-8-aza-3-siladodecan-6-yl methanesulfonate→(2R,3S)-3-((tert-butoxycarbonyl)amino)-1-hydroxy-4-phenylbutan-2-yl methanesulfonate
tert-butyl hydrazinecarboxylate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→methyl 4-cyanobenzoate→methyl 4-(pyridin-2-yl)benzoate→4-(pyridin-2-yl)benzoic acid→(isobutyl carbonic) 4-(pyridin-2-yl)benzoic anhydride→(S)-tert-butyl (1-oxo-3-phenylpropan-2-yl)carbamate→(1R,2S)-2-((tert-butoxycarbonyl)amino)-1-cyano-3-phenylpropyl 4-(pyridin-2-yl)benzoate→tert-butyl (E)-2-((2R,3S)-3-((tert-butoxycarbonyl)amino)-4-phenyl-2-((4-(pyridin-2-yl)benzoyl)oxy)butylidene)hydrazine-1-carboxylate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-4-phenyl-2-((4-(pyridin-2-yl)benzoyl)oxy)butyl)hydrazine-1-carboxylate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzoyl)hydrazine-1-carboxylate
4-bromobenzaldehyde→1-bromo-4-(dimethoxymethyl)benzene→2-bromopyridine→4-(pyridin-2-yl)benzaldehyde→tert-butyl hydrazinecarboxylate→tert-butyl (E)-2-(4-(pyridin-2-yl)benzylidene)hydrazine-1-carboxylate→tert-butyl 2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→tert-butyl ((S)-1-((R)-oxiran-2-yl)-2-phenylethyl)carbamate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→(2S,3S)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol→(S)-2-((methoxycarbonyl)amino)-3,3-dimethylbutanoic acid
2-bromopyridine→4-(pyridin-2-yl)benzaldehyde→tert-butyl hydrazinecarboxylate→tert-butyl (E)-2-(4-(pyridin-2-yl)benzylidene)hydrazine-1-carboxylate→tert-butyl 2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→tert-butyl ((S)-1-((R)-oxiran-2-yl)-2-phenylethyl)carbamate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→(2S,3S)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol→(S)-2-((methoxycarbonyl)amino)-3,3-dimethylbutanoic acid→(4-formylphenyl)boronic acid→tert-butyl ((2S,3R)-3,4-dihydroxy-1-phenylbutan-2-yl)carbamate→(6R,7S)-7-benzyl-2,2,3,3,11,11-hexamethyl-9-oxo-4,10-dioxa-8-aza-3-siladodecan-6-yl methanesulfonate→(2R,3S)-3-((tert-butoxycarbonyl)amino)-1-hydroxy-4-phenylbutan-2-yl methanesulfonate
tert-butyl hydrazinecarboxylate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate→methyl 4-cyanobenzoate→methyl 4-(pyridin-2-yl)benzoate→4-(pyridin-2-yl)benzoic acid→(isobutyl carbonic) 4-(pyridin-2-yl)benzoic anhydride→(S)-tert-butyl (1-oxo-3-phenylpropan-2-yl)carbamate→(1R,2S)-2-((tert-butoxycarbonyl)amino)-1-cyano-3-phenylpropyl 4-(pyridin-2-yl)benzoate→tert-butyl (E)-2-((2R,3S)-3-((tert-butoxycarbonyl)amino)-4-phenyl-2-((4-(pyridin-2-yl)benzoyl)oxy)butylidene)hydrazine-1-carboxylate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-4-phenyl-2-((4-(pyridin-2-yl)benzoyl)oxy)butyl)hydrazine-1-carboxylate→tert-butyl 2-((2S,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)-2-(4-(pyridin-2-yl)benzoyl)hydrazine-1-carboxylate
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.