← Back to patent-cliff list
CAS 871-78-3
N-[2-(Acetamido)ethyl]acetamide
Codes: Oxymetazoline Hydrochloride-011
Application context (from source-drug indications)
AnaesthesiaOxymetazoline Hydrochloride/Tetracaine HydrochloridePeriapical periodontitisOxymetazoline Hydrochloride/Tetracaine HydrochlorideDental cariesOxymetazoline Hydrochloride/Tetracaine HydrochlorideNasal congestionOxymetazoline HydrochlorideCongestionOxymetazoline HydrochloridePtosisOxymetazoline HydrochlorideFunctional faecal incontinenceOxymetazoline HydrochlorideRosaceaOxymetazoline HydrochlorideRashOxymetazoline Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Oxymetazoline Hydrochloride/Tetracaine Hydrochloride | Tier C — Watch / trade | - |
| Oxymetazoline Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Oxymetazoline Hydrochloride/Tetracaine HydrochlorideOptimised routesteps: 6total yield: 26g(Oxymetazoline hydrochloride (API))
(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetonitrile→Ethane-1,2-diamine→N-[2-(Acetamido)ethyl]acetamide→6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol→(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetyl chloride→(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetic acid→Ethane-1,2-diamine 4-methylbenzenesulfonate→2-(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetamide→2-Bromoethanamine hydrobromide→Ethylene dibromide→Ethyl 2-(4-tert-butyl-3-hydroxy-2,6-dimethylphenyl)ethanimidoate hydrochloride
Oxymetazoline HydrochlorideOptimised routesteps: 6total yield: 26g(Oxymetazoline hydrochloride (API))
(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetonitrile→Ethane-1,2-diamine→N-[2-(Acetamido)ethyl]acetamide→6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol→(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetyl chloride→(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetic acid→Ethane-1,2-diamine 4-methylbenzenesulfonate→2-(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetamide→2-Bromoethanamine hydrobromide→Ethylene dibromide→Ethyl 2-(4-tert-butyl-3-hydroxy-2,6-dimethylphenyl)ethanimidoate hydrochloride
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.