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CAS 875446-35-8
(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-(2-iodo-5-(trifluoromethyl)benzyl)-4-methyloxazolidin-2-one
Codes: ANAC-008
Application context (from source-drug indications)
HypercholesterolaemiaAnacetrapibCardiac and vascular disordersAnacetrapibDyslipidaemiaAnacetrapibAtherosclerosisAnacetrapibHyperlipoproteinaemia type IIAnacetrapibHomozygous familial hypercholesterolaemiaAnacetrapib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Anacetrapib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-iodo-4-(trifluoromethyl)aniline→2-amino-5-(trifluoromethyl)benzonitrile→2-iodo-5-(trifluoromethyl)benzonitrile →2-iodo-5-(trifluoromethyl)benzoic acid→[2-iodo-5-(trifluoromethyl)phenyl]methanol →2-(bromomethyl)-1-iodo-4-(trifluoromethyl)benzene→(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one→(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-(2-iodo-5-(trifluoromethyl)benzyl)-4-methyloxazolidin-2-one→(4-fluoro-5-isopropyl-2-methoxyphenyl)boronic acid→3,5-bis(trifluoromethyl)benzaldehyde→nitroethane→1-(3,5-bis(trifluoromethyl)phenyl)-2-nitropropan-1-ol→2-amino-1-(3,5-bis(trifluoromethyl)phenyl)propan-1-ol→5-(3,5-bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one→1-(2-fluoro-4-methoxyphenyl)ethan-1-one→2-(2-fluoro-4-methoxyphenyl)propan-2-ol→2-fluoro-1-isopropyl-4-methoxybenzene→1-bromo-4-fluoro-5-isopropyl-2-methoxybenzene
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