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CAS 87691-87-0
3-(piperazin-1-yl)benzo[d]isothiazole
Codes: LURA-004
Application context (from source-drug indications)
Major depressive disorderLurasidone HydrochlorideSchizophreniaLurasidone HydrochlorideManiaLurasidone HydrochlorideDepressive disorderLurasidone Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lurasidone Hydrochloride | Tier B — Position early | 2028 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-(piperazin-1-yl)benzo[d]isothiazole→(3aR,7aR)-4'-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1'-piperazin]-2-ium methanesulfonate→(3aR,4S,7R,7aS)-hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione→(3aR,7aR)-hexahydroisobenzofuran-1,3-dione→((1R,2R)-cyclohexane-1,2-diyl)dimethanol→((1R,2R)-cyclohexane-1,2-diyl)bis(methylene) dimethanesulfonate
3-(piperazin-1-yl)benzo[d]isothiazole→((1R,2R)-2-(aminomethyl)cyclohexyl)methanol→(3aR,4S,7R,7aS)-hexahydro-4,7-methanoisobenzofuran-1,3-dione→(3aR,4S,7R,7aS)-2-(((1R,2R)-2-(hydroxymethyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione→((1R,2R)-2-(((3aR,4S,7R,7aS)-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl)methyl)cyclohexyl)methyl methanesulfonate
3-(piperazin-1-yl)benzo[d]isothiazole→(3aR,7aR)-4'-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1'-piperazin]-2-ium methanesulfonate→(3aR,4S,7R,7aS)-hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione→((1R,2R)-cyclohexane-1,2-diyl)bis(methylene) dimethanesulfonate
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