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CAS 880160-64-5
methyl 5-fluoro-2-((4-(((methoxycarbonyl)(methyl)amino)methyl)phenyl)ethynyl)-3-nitrobenzoate
Codes: RUCA-008
Application context (from source-drug indications)
Prostate cancerRucaparib CamsylatePeritoneal cancerRucaparib CamsylateEpithelial ovarian cancerRucaparib CamsylateFallopian tube cancerRucaparib CamsylateOvarian cancerRucaparib CamsylateCastration-resistant prostate cancerRucaparib Camsylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Rucaparib Camsylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-bromobenzaldehyde→ethynyltrimethylsilane→4-((trimethylsilyl)ethynyl)benzaldehyde→N-methyl-1-(4-((trimethylsilyl)ethynyl)phenyl)methanamine→methyl methyl(4-((trimethylsilyl)ethynyl)benzyl)carbamate→methyl 4-ethynylbenzyl(methyl)carbamate→methyl 5-fluoro-2-hydroxy-3-nitrobenzoate→methyl 5-fluoro-2-((4-(((methoxycarbonyl)(methyl)amino)methyl)phenyl)ethynyl)-3-nitrobenzoate→methyl 3-amino-5-fluoro-2-((4-(((methoxycarbonyl)(methyl)amino)methyl)phenyl)ethynyl)benzoate→methyl 6-fluoro-2-(4-(((methoxycarbonyl)(methyl)amino)methyl)phenyl)-1H-indole-4-carboxylate→(E)-N,N-dimethyl-2-nitroethenamine→(E)-methyl 6-fluoro-2-(4-(((methoxycarbonyl)(methyl)amino)methyl)phenyl)-3-(2-nitrovinyl)-1H-indole-4-carboxylate→methyl 6-fluoro-2-(4-(((methoxycarbonyl)(methyl)amino)methyl)phenyl)-3-(2-nitroethyl)-1H-indole-4-carboxylate→methyl 4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)benzyl(methyl)carbamate→5-fluoro-2-hydroxybenzoic acid→methyl 5-fluoro-2-hydroxybenzoate
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