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CAS 90003-74-0

2,2-Dichloro-N-(5-chloro-2,4-disulfamoylphenyl)acetamide

Codes: Trichlormethiazide-005

Application context (from source-drug indications)

HypertensionIrbesartan/TrichlormethiazideHypertensionTrichlormethiazideOedemaTrichlormethiazide

Source drugs (routes using this intermediate)

DrugTierExpiry
Irbesartan/TrichlormethiazideTier C — Watch / trade-
TrichlormethiazideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Irbesartan/TrichlormethiazideOptimised routesteps: 8total yield: /
4-Amino-6-chlorobenzene-1,3-disulfonyl dichloride→2,2-Dichloroacetic acid chloride→Dichloroacetic anhydride→4-Chloro-6-(2,2-dichloroacetamido)benzene-1,3-disulfonyl dichloride→2,2-Dichloro-N-(5-chloro-2,4-disulfamoylphenyl)acetamide→6-Chloro-3-(dichloromethyl)-1,1-dioxo-1,2-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide→2,2-Dichloroacetonitrile→Ethyl 2,2-dichloroethanimidoate hydrochloride→2,2-Dichloro-1,1,1-triethoxyethane→4-Amino-6-chlorobenzene-1,3-disulfonamide→Dichloroacetaldehyde→1,1-Dichloro-2,2-diethoxyethane
TrichlormethiazideOptimised routesteps: 8total yield: /
4-Amino-6-chlorobenzene-1,3-disulfonyl dichloride→2,2-Dichloroacetic acid chloride→Dichloroacetic anhydride→4-Chloro-6-(2,2-dichloroacetamido)benzene-1,3-disulfonyl dichloride→2,2-Dichloro-N-(5-chloro-2,4-disulfamoylphenyl)acetamide→6-Chloro-3-(dichloromethyl)-1,1-dioxo-1,2-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide→2,2-Dichloroacetonitrile→Ethyl 2,2-dichloroethanimidoate hydrochloride→2,2-Dichloro-1,1,1-triethoxyethane→4-Amino-6-chlorobenzene-1,3-disulfonamide→Dichloroacetaldehyde→1,1-Dichloro-2,2-diethoxyethane

Intermediates available on this site

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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.