CAS 906673-54-9

4-(4-bromo-3-formylphenoxy)benzonitrile

Codes: CRISA-001

Application context (from source-drug indications)

Atopic dermatitisCrisaboroleDermatitisCrisaboroleEczemaCrisaboroleAlopecia areataCrisaboroleLocalised sclerodermaCrisaborolePlaque psoriasisCrisaborole

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Crisaborole	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

CrisaboroleOriginator routesteps: 3total yield: /

4-(4-bromo-3-formylphenoxy)benzonitrile→4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile→chloro(methoxy)methane→4-(4-bromo-3-((methoxymethoxy)methyl)phenoxy)benzonitrile

CrisaboroleOptimised routesteps: 2total yield: /

4-(4-bromo-3-formylphenoxy)benzonitrile→2-bromo-5-hydroxybenzaldehyde→ethane-1,2-diol→4-bromo-3-(1,3-dioxolan-2-yl)phenol→4-fluorobenzonitrile

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Qualified Partner — East China API Works	4-(4-Bromo-3-formyl-phenoxy)-benzonitrile Pharmaceutical Intermediates	On request	On request	On request	—

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