4'-(bromomethyl)-[1,1'-biphenyl]-2-carbaldehyde (911314-60-8) intermediate

Application context (from source-drug indications)

HypertensionTelmisartan/Amlodipine Besylate/HydrochlorothiazideHypertensionRosuvastatin Calcium/TelmisartanHyperlipidaemiaRosuvastatin Calcium/TelmisartanHypertensionAzilsartanEssential hypertensionAzilsartanType 2 diabetesAzilsartanObesityAzilsartanDiabetesAzilsartanHypertensionAmlodipine Besylate/TelmisartanHypertensionTelmisartanBreast cancerTelmisartanCardiomyopathyTelmisartanAlzheimer's diseaseTelmisartanRisk-reduction measureTelmisartanMyocardial infarctionTelmisartan

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Telmisartan/Amlodipine Besylate/Hydrochlorothiazide	Tier C — Watch / trade	-
Rosuvastatin Calcium/Telmisartan	Tier C — Watch / trade	-
Azilsartan	Tier C — Watch / trade	-
Amlodipine Besylate/Telmisartan	Tier C — Watch / trade	-
Telmisartan	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Telmisartan/Amlodipine Besylate/HydrochlorothiazideOptimised routesteps: 4total yield: 0.20 g

1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→4'-methyl-[1,1'-biphenyl]-2-carbonitrile→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbaldehyde→4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carbaldehyde

Rosuvastatin Calcium/TelmisartanOptimised routesteps: 4total yield: 0.20 g

1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→4'-methyl-[1,1'-biphenyl]-2-carbonitrile→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbaldehyde→4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carbaldehyde

AzilsartanOptimised routesteps: 5total yield: 9.2 g

methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate→methyl 2-ethoxy-1H-benzo[d]imidazole-7-carboxylate→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbaldehyde→methyl 2-ethoxy-1-((2'-formyl-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate→methyl (E)-2-ethoxy-1-((2'-((hydroxyimino)methyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate→methyl (Z)-1-((2'-(chloro(hydroxyimino)methyl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Amlodipine Besylate/TelmisartanOptimised routesteps: 4total yield: 0.20 g

1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→4'-methyl-[1,1'-biphenyl]-2-carbonitrile→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbaldehyde→4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carbaldehyde

TelmisartanOptimised routesteps: 4total yield: 0.20 g

1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→4'-methyl-[1,1'-biphenyl]-2-carbonitrile→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbaldehyde→4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carbaldehyde

Intermediates available on this site

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