CAS 915087-25-1

4-amino-2-fluoro-N-methylbenzamide

Codes: ENZA-004, APAL-013

Application context (from source-drug indications)

Hormone-sensitive prostate cancerEnzalutamideCastration-resistant prostate cancerEnzalutamideProstate cancerEnzalutamideCastration-resistant prostate cancerApalutamideProstate cancerApalutamide

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Enzalutamide	Tier A — Act now	2027
Apalutamide	Tier A — Act now	2030

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

EnzalutamideOriginator routesteps: 5total yield: 15 mg

2-fluoro-1-methyl-4-nitrobenzene→2-fluoro-4-nitrobenzoic acid→2-fluoro-N-methyl-4-nitrobenzamide→4-amino-2-fluoro-N-methylbenzamide→2-hydroxy-2-methylpropanenitrile→4-((2-cyanopropan-2-yl)amino)-2-fluoro-N-methylbenzamide→4-isothiocyanato-2-(trifluoromethyl)benzonitrile

EnzalutamideOptimised routesteps: 2total yield: 152.3 g

4-amino-2-fluoro-N-methylbenzamide→4-isothiocyanato-2-(trifluoromethyl)benzonitrile→methyl 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoate→methyl 2-bromo-2-methylpropanoate

ApalutamideOriginator routesteps: 11total yield: /

3-(trifluoromethyl)pyridin-2-ol→5-iodo-3-(trifluoromethyl)pyridin-2-ol→2-chloro-5-iodo-3-(trifluoromethyl)pyridine→(4-methoxyphenyl)methanamine→6-chloro-N-(4-methoxybenzyl)-5-(trifluoromethyl)pyridin-3-amine→5-((4-methoxybenzyl)amino)-3-(trifluoromethyl)picolinonitrile→5-amino-3-(trifluoromethyl)picolinonitrile→5-isothiocyanato-3-(trifluoromethyl)picolinonitrile→4-((1-cyanocyclobutyl)amino)-2-fluoro-N-methylbenzamide→2,4-difluorobenzoyl chloride→2,4-difluoro-N-methylbenzamide→2-fluoro-4-((4-methoxybenzyl)amino)-N-methylbenzamide→4-amino-2-fluoro-N-methylbenzamide→cyclobutanone

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	5-Amino-3-(trifluoromethyl)picolinonitrile Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	N-Boc-1-aminocyclobutanecarboxylic acid Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	1-amino-N-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]Cyclobutanecarboxamide Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.