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CAS 918344-20-4
(1-Hydroxycyclohexyl)(4-hydroxyphenyl)acetonitrile
Codes: DESV-021, Desvenlafaxine-018
Application context (from source-drug indications)
Depressive disorderDesvenlafaxine Succinate HydrateMajor depressive disorderDesvenlafaxine Succinate HydrateDepressionDesvenlafaxine Succinate HydrateDiabetic neuropathyDesvenlafaxine Succinate HydratePainDesvenlafaxine Succinate HydrateFibromyalgiaDesvenlafaxine Succinate HydrateMajor depressive disorderDesvenlafaxineDepressive disorderDesvenlafaxine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Desvenlafaxine Succinate Hydrate | Tier C — Watch / trade | - |
| Desvenlafaxine | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(4-Hydroxyphenyl)acetonitrile→Cyclohexanone→(1-Hydroxycyclohexyl)(4-hydroxyphenyl)acetonitrile→4-[2-Amino-1-(1-hydroxycyclohexyl)ethyl]phenol→2-[4-(Oxan-2-yloxy)phenyl]acetonitrile→[4-(Benzyloxy)phenyl]acetonitrile→2-(1-Hydroxycyclohexyl)-2-[4-(oxan-2-yloxy)phenyl]acetonitrile→[4-(Benzyloxy)phenyl](1-hydroxycyclohexyl)acetonitrile→Iodomethane→4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol
2-(4-Methoxyphenyl)acetonitrile→2-(4-Hydroxyphenyl)acetonitrile→[4-[(2-Methoxyethoxy)methoxy]phenyl]acetonitrile→Cyclohexanone→(1-Hydroxycyclohexyl)[4-[(2-methoxyethoxy)methoxy]phenyl]acetonitrile→Dimethylamine hydrochloride→Desvenlafaxine-036→4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol→(1-Hydroxycyclohexyl)(4-hydroxyphenyl)acetonitrile
Intermediates available on this site
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