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CAS 918504-27-5
N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Codes: VEMF-008
Application context (from source-drug indications)
Erdheim-Chester diseaseVemurafenibMelanomaVemurafenibHistiocytosisVemurafenibLangerhans cell histiocytosisVemurafenibNon-Hodgkin lymphomaVemurafenibHepatoblastomaVemurafenib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Vemurafenib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2,4-difluoroaniline→benzyl 3-amino-2,6-difluorobenzoate→propane-1-sulfonyl chloride→benzyl 2,6-difluoro-3-(propylsulfonamido)benzoate→2,6-difluoro-3-(propylsulfonamido)benzoic acid→2,6-difluoro-3-(propylsulfonamido)benzoyl chloride→5-bromo-1H-pyrrolo[2,3-b]pyridine→N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide→(4-chlorophenyl)boronic acid
2,6-difluoro-3-(propylsulfonamido)benzoic acid→5-bromo-1H-pyrrolo[2,3-b]pyridine→N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide→(4-chlorophenyl)boronic acid→5-bromopyridin-2-amine→(E)-2-(2-ethoxyvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→5-bromo-3-iodopyridin-2-amine→2,6-dichlorobenzoyl chloride→N-(3-(5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide→N-(3-(5-(4-chlorophenyl)-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
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