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CAS 927801-17-0
6-Bromo-3,4-dichloroquinoline
Codes: (XX)1055986-1-c
Application context (from source-drug indications)
AcromegalyPaltusotineIntestinal neoplasmPaltusotine恶性类癌综合征PaltusotineDiarrhoeaPaltusotineLiver cancerPaltusotine回肠肿瘤Paltusotine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paltusotine | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1,1-Dimethylethyl piperidin-4-ylcarbamate→N-Boc-1-(6-bromo-3-chloroquinolin-4-yl)piperidin-4-amine→(3,5-Difluorophenyl)Boranediol→3-[4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile→6-Bromo-3,4-dichloroquinoline→2-[(2-Methoxyethoxy)methoxy]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile→N-Boc-1-(3-chloro-6-[3-cyano-2-(2-methoxy-ethoxymethoxy)-phenyl]-quinolin-4-yl)-piperidin-4-amine→tert-Butyl [1-[3-chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-4-yl]piperidin-4-yl]carbamate→3-Bromo-2-[(2-methoxyethoxy)methoxy]benzonitrile→tert-Butyl [1-[6-[3-cyano-2-[(2-methoxyethoxy)methoxy]phenyl]-3-(3,5-difluorophenyl)quinolin-4-yl]piperidin-4-yl]carbamate
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