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CAS 929904-95-0
N-(5-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-oxo-4,5-dihydro-1,3,5-triazin-2-yl)-2-phenoxyacetamide
Codes: GUAD-005
Application context (from source-drug indications)
软骨肉瘤Guadecitabine SodiumNon-small cell lung cancerGuadecitabine SodiumMelanomaGuadecitabine SodiumSmall cell lung cancerGuadecitabine SodiumUrothelial carcinomaGuadecitabine SodiumPeritoneal cancerGuadecitabine Sodium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Guadecitabine Sodium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one→4-amino-1-((2R,4S,5R)-4-((trimethylsilyl)oxy)-5-(((trimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one→2-phenoxyacetic anhydride→N-(4-oxo-5-((2R,4S,5R)-4-((trimethylsilyl)oxy)-5-(((trimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-4,5-dihydro-1,3,5-triazin-2-yl)-2-phenoxyacetamide→N-(5-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-oxo-4,5-dihydro-1,3,5-triazin-2-yl)-2-phenoxyacetamide→GUAD-006→3-((bis(diisopropylamino)phosphaneyl)oxy)propanenitrile→GUAD-008→GUAD-009→GUAD-010→GUAD-011→GUAD-012
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