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CAS 936221-72-6
1-(tert-butyl) 8-methyl (E)-2-((naphthalen-1-yloxy)methyl)oct-2-enedioate
Codes: CG-200745-007
Application context (from source-drug indications)
Pancreatic cancerivaltinostatMyelodysplastic syndromeivaltinostatSolid tumourivaltinostatFibrosisivaltinostatHaematological malignancyivaltinostat
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| ivaltinostat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
oxepan-2-one→methyl 6-hydroxyhexanoate→methyl 6-oxohexanoate→1-(tert-butyl) 8-methyl 3-hydroxy-2-methyleneoctanedioate→1-(tert-butyl) 8-methyl (Z)-2-(bromomethyl)oct-2-enedioate→naphthalen-1-ol→1-(tert-butyl) 8-methyl (E)-2-((naphthalen-1-yloxy)methyl)oct-2-enedioate→(E)-8-methoxy-2-((naphthalen-1-yloxy)methyl)-8-oxooct-2-enoic acid→N1,N1-dimethylpropane-1,3-diamine→methyl (E)-8-((3-(dimethylamino)propyl)amino)-7-((naphthalen-1-yloxy)methyl)-8-oxooct-6-enoate→(E)-8-((3-(dimethylamino)propyl)amino)-7-((naphthalen-1-yloxy)methyl)-8-oxooct-6-enoic acid→O-(tetrahydro-2H-pyran-2-yl)hydroxylamine→(E)-N1-(3-(dimethylamino)propyl)-2-((naphthalen-1-yloxy)methyl)-N8-((tetrahydro-2H-pyran-2-yl)oxy)oct-2-enediamide
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