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CAS 937179-77-6
(2S,5S)-2-(tert-butyl)-5-cyclopentyl-5-phenyl-1,3-dioxolan-4-one
Codes: GLYC-011
Application context (from source-drug indications)
AsthmaBudesonide/Formoterol fumarate/Glycopyrronium BromideChronic obstructive pulmonary diseaseBudesonide/Formoterol fumarate/Glycopyrronium BromideChronic obstructive pulmonary diseaseIndacaterol Maleate/Glycopyrronium BromideSialorrhoeaGlycopyrronium BromideChronic obstructive pulmonary diseaseGlycopyrronium BromideDuodenal ulcerGlycopyrronium BromideGastric ulcerGlycopyrronium BromideGastritisGlycopyrronium BromideAnaesthesiaGlycopyrronium Bromide
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Budesonide/Formoterol fumarate/Glycopyrronium Bromide | Tier B — Position early | - |
| Indacaterol Maleate/Glycopyrronium Bromide | Tier B — Position early | - |
| Glycopyrronium Bromide | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
bromocyclopentane→(S)-2-hydroxy-2-phenylacetic acid→(2S,5S)-2-(tert-butyl)-5-phenyl-1,3-dioxolan-4-one→(2S,5S)-2-(tert-butyl)-5-cyclopentyl-5-phenyl-1,3-dioxolan-4-one→(S)-2-cyclopentyl-2-hydroxy-2-phenylacetic acid→methyl (S)-2-cyclopentyl-2-hydroxy-2-phenylacetate→(R)-1-methylpyrrolidin-3-ol→(R)-1-methylpyrrolidin-3-yl (S)-2-cyclopentyl-2-hydroxy-2-phenylacetate
bromocyclopentane→(S)-2-hydroxy-2-phenylacetic acid→(2S,5S)-2-(tert-butyl)-5-phenyl-1,3-dioxolan-4-one→(2S,5S)-2-(tert-butyl)-5-cyclopentyl-5-phenyl-1,3-dioxolan-4-one→(S)-2-cyclopentyl-2-hydroxy-2-phenylacetic acid→methyl (S)-2-cyclopentyl-2-hydroxy-2-phenylacetate→(R)-1-methylpyrrolidin-3-ol→(R)-1-methylpyrrolidin-3-yl (S)-2-cyclopentyl-2-hydroxy-2-phenylacetate
bromocyclopentane→(S)-2-hydroxy-2-phenylacetic acid→(2S,5S)-2-(tert-butyl)-5-phenyl-1,3-dioxolan-4-one→(2S,5S)-2-(tert-butyl)-5-cyclopentyl-5-phenyl-1,3-dioxolan-4-one→(S)-2-cyclopentyl-2-hydroxy-2-phenylacetic acid→methyl (S)-2-cyclopentyl-2-hydroxy-2-phenylacetate→(R)-1-methylpyrrolidin-3-ol→(R)-1-methylpyrrolidin-3-yl (S)-2-cyclopentyl-2-hydroxy-2-phenylacetate
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