CAS 937273-31-9

2-((allyloxy)methyl)-1-(2-chloroethoxy)-4-nitrobenzene

Codes: PACR-006

Application context (from source-drug indications)

MyelofibrosisPacritinib CitrateThrombocytopeniaPacritinib CitrateAcute myeloid leukaemiaPacritinib CitrateEssential thrombocythaemiaPacritinib CitratePolycythaemia veraPacritinib CitrateChronic myelomonocytic leukaemiaPacritinib Citrate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Pacritinib Citrate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Pacritinib CitrateOriginator routesteps: 8total yield: /

2-hydroxy-5-nitrobenzaldehyde→1-bromo-2-chloroethane→2-(2-chloroethoxy)-5-nitrobenzaldehyde→(2-(2-chloroethoxy)-5-nitrophenyl)methanol→3-bromoprop-1-ene→2-((allyloxy)methyl)-1-(2-chloroethoxy)-4-nitrobenzene→3-((allyloxy)methyl)-4-(2-chloroethoxy)aniline→4-(3-((allyloxy)methyl)phenyl)-2-chloropyrimidine→PACR-009→pyrrolidine→2,4-dichloropyrimidine→(3-(hydroxymethyl)phenyl)boronic acid→(3-(2-chloropyrimidin-4-yl)phenyl)methanol

Pacritinib CitrateOptimised routesteps: 4total yield: /

2-((allyloxy)methyl)-1-(2-chloroethoxy)-4-nitrobenzene→4-(3-((allyloxy)methyl)phenyl)-2-chloropyrimidine→pyrrolidine→1-(2-(2-((allyloxy)methyl)-4-nitrophenoxy)ethyl)pyrrolidine→3-((allyloxy)methyl)-4-(2-(pyrrolidin-1-yl)ethoxy)aniline→N-(3-((allyloxy)methyl)-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-4-(3-((allyloxy)methyl)phenyl)pyrimidin-2-amine

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Qualified Partner — East China API Works	2-((allyloxy)Methyl)-1-(2-chl oroethoxy)-4-nitrob Pharmaceutical Intermediates	On request	On request	On request	—

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