CAS 94-09-7

Ethyl 4-aminobenzoate4-Aminobenzoic acid ethyl ester4-(Ethoxycarbonyl)anilineethyl 4-aminobenzoate

Codes: Tetracaine-025, Folic Acid-075, MITAP-001

Application context (from source-drug indications)

AnaesthesiaOxymetazoline Hydrochloride/Tetracaine HydrochloridePeriapical periodontitisOxymetazoline Hydrochloride/Tetracaine HydrochlorideDental cariesOxymetazoline Hydrochloride/Tetracaine HydrochlorideEssential hypertensionEnalapril Maleate/Folic AcidAnaesthesiaTetracaine HydrochlorideRetinitis pigmentosaTetracaine HydrochloridePainTetracaine HydrochlorideMegaloblastic anaemiaFolic AcidFolate deficiencyFolic AcidNeural tube defectFolic AcidAnaemiaFolic AcidHot flushesFolic AcidHyperhomocysteinaemiaFolic Acidα-地中海贫血Mitapivat sulfateBeta thalassaemiaMitapivat sulfate丙酮酸激酶缺乏症Mitapivat sulfateHaemolytic anaemiaMitapivat sulfate先天性溶血性贫血Mitapivat sulfateSickle cell diseaseMitapivat sulfate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Oxymetazoline Hydrochloride/Tetracaine Hydrochloride	Tier C — Watch / trade	-
Enalapril Maleate/Folic Acid	Tier C — Watch / trade	-
Tetracaine Hydrochloride	Tier C — Watch / trade	-
Folic Acid	Tier C — Watch / trade	-
Mitapivat sulfate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Oxymetazoline Hydrochloride/Tetracaine HydrochlorideOptimised routesteps: 5total yield: /

4-Bromobenzoyl chloride→2-(Dimethylamino)ethyl 4-bromobenzoate→Ethyl 4-aminobenzoate→n-Butyl bromide→N,N-Dimethylaminoethanol→Monobutylamine→4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester→4-(Butylamino)benzoic acid ethyl ester→4-Aminobenzoic acid

Oxymetazoline Hydrochloride/Tetracaine HydrochlorideOptimised routesteps: 3total yield: /

Ethyl 4-nitrobenzoate→4-Aminobenzoic acid ethyl ester→Butyraldehyde→4-(Butylamino)benzoic acid ethyl ester→N,N-Dimethyl-2-hydroxyethylamine→4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester

Enalapril Maleate/Folic AcidOptimised routesteps: 7total yield: 1.5g(Folic Acid (Free))

4-(Ethoxycarbonyl)aniline→(+/-)-2-(Chloromethyl)oxirane→Ethyl 4-[(3-chloro-2-hydroxypropyl)amino]benzoate→Ethyl 4-[(tert-butoxycarbonyl)(3-chloro-2-hydroxypropyl)amino]benzoate→Ethyl 4-[(tert-butoxycarbonyl)(3-chloro-2-oxopropyl)amino]benzoate→2,4,5-Triamino-6-hydroxypyrimidine sulfate→Ethyl 4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](tert-butoxycarbonyl)amino]benzoate→4-[(2-Amino-4-oxo-3H-pteridin-6-yl)methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]benzoic acid→(S)-Glutamic acid diethyl ester→Diethyl N-(4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](tert-butoxycarbonyl)amino]benzoyl)-L-glutamate

Tetracaine HydrochlorideOptimised routesteps: 5total yield: /

Tetracaine HydrochlorideOptimised routesteps: 3total yield: /

Folic AcidOptimised routesteps: 7total yield: 1.5g(Folic Acid (Free))

Mitapivat sulfateOptimised routesteps: 5total yield: 0.035 g

ethyl 4-aminobenzoate→quinoline-8-sulfonyl chloride→ethyl 4-(quinoline-8-sulfonamido)benzoate→4-(quinoline-8-sulfonamido)benzoic acid→tert-butyl piperazine-1-carboxylate→tert-butyl 4-(4-(quinoline-8-sulfonamido)benzoyl)piperazine-1-carboxylate→N-(4-(piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide→cyclopropanecarbaldehyde→Mitapivat

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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.