CAS 941289-95-8

(4R)-1-((S)-1-amino-1-oxobutan-2-yl)-2-oxo-4-propylpyrrolidine-3-carboxylic acid

Codes: BRIV-025

Application context (from source-drug indications)

Partial-onset seizureBrivaracetamEpilepsyBrivaracetamSeizureBrivaracetam

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Brivaracetam	Tier C — Watch / trade	2028

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

BrivaracetamOptimised routesteps: 10total yield: 0.13 g

(S)-2-aminobutanamide→(S)-2-((R)-2-oxo-4-propylpyrrolidin-1-yl)butanamide→pent-1-ene→(R)-pentane-1,2-diol→(4R)-4-propyl-1,3,2-dioxathiolane 2-oxide→(R)-4-propyl-1,3,2-dioxathiolane 2,2-dioxide→dimethyl malonate→(R)-dimethyl 2-propylcyclopropane-1,1-dicarboxylate→(R)-2-propylcyclopropane-1,1-dicarboxylic acid→(R)-6,6-dimethyl-1-propyl-5,7-dioxaspiro[2.5]octane-4,8-dione→(4R)-1-((S)-1-amino-1-oxobutan-2-yl)-2-oxo-4-propylpyrrolidine-3-carboxylic acid→1-((S)-1-amino-1-oxobutan-2-yl)-2-oxo-5-propylpyrrolidine-3-carboxylic acid→(4R)-methyl 1-((S)-1-amino-1-oxobutan-2-yl)-2-oxo-4-propylpyrrolidine-3-carboxylate→methyl 1-((S)-1-amino-1-oxobutan-2-yl)-2-oxo-5-propylpyrrolidine-3-carboxylate→(2S)-2-(2-oxo-5-propylpyrrolidin-1-yl)butanamide

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Taizhou GMP-like Site	Brivaracetam Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one Pharmaceutical Intermediates	On request	On request	On request	—

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