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CAS 941685-68-3

3-cyclopentylpropiolonitrile

Codes: RUXO-011

Application context (from source-drug indications)

Atopic dermatitisRuxolitinib PhosphateVitiligoRuxolitinib PhosphateGraft-versus-host diseaseRuxolitinib PhosphateMyelofibrosisRuxolitinib PhosphatePolycythaemia veraRuxolitinib Phosphate

Source drugs (routes using this intermediate)

DrugTierExpiry
Ruxolitinib PhosphateTier A — Act now2028

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Ruxolitinib PhosphateOptimised routesteps: 9total yield: 634.2 g
4-chloro-7H-pyrrolo[2,3-d]pyrimidine→(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate→1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole→(4-(1-(1-ethoxyethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate→(4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate→3-cyclopentylpropiolonitrile→(Z)-(4-(1-(2-cyano-1-cyclopentylvinyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate→(Z)-(4-(1-(3-amino-1-cyclopentyl-3-oxoprop-1-en-1-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate→(R)-(4-(1-(3-amino-1-cyclopentyl-3-oxopropyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate→(R)-(4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

SupplierProductPrice bandMOQLead timeQualificationsAction
Unibest Nantong cGMP Site1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Pharmaceutical Intermediates
On requestOn requestOn request
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Unibest Taizhou GMP-like Site-CYCLOPENTYLACRYLONITRILE
Pharmaceutical Intermediates
On requestOn requestOn request
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Qualified Partner — East China API WorksCyclopentanecarbaldehyde
Pharmaceutical Intermediates
On requestOn requestOn request
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Unibest Nantong cGMP Site4-Chloropyrrolo[2,3-d]pyrimidine
Pharmaceutical Intermediates
On requestOn requestOn request
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Unibest Taizhou GMP-like Site4-(1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
Pharmaceutical Intermediates
On requestOn requestOn request
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Qualified Partner — East China API Works3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
Pharmaceutical Intermediates
On requestOn requestOn request
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Unibest Nantong cGMP Site(3R)-3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
Pharmaceutical Intermediates
On requestOn requestOn request
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Unibest Taizhou GMP-like Site(S)-3-cyclopentyl-3-hydrazinylpropanenitrile L-tartaric acid salt dihydrate
Pharmaceutical Intermediates
On requestOn requestOn request
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Qualified Partner — East China API Works2-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetic acid
Pharmaceutical Intermediates
On requestOn requestOn request
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Unibest Nantong cGMP Site4-methyl-7H-pyrrolo[2,3-d]pyrimidine
Pharmaceutical Intermediates
On requestOn requestOn request
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Unibest Taizhou GMP-like Site(R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
Pharmaceutical Intermediates
On requestOn requestOn request
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Qualified Partner — East China API Works(4-(1-(2-Cyano-1-cyclopentylethyl)-1h-pyrazol-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
Pharmaceutical Intermediates
On requestOn requestOn request
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Unibest Nantong cGMP Site4-CHLORO-7-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-7H-PYRROLO[2,3-D]PYRIMIDINE
Pharmaceutical Intermediates
On requestOn requestOn request
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Unibest Taizhou GMP-like Site1H-Pyrazole-1-propanamide, 4-bromo-β-cyclopentyl-, (βR)-
Pharmaceutical Intermediates
On requestOn requestOn request
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Qualified Partner — East China API Works(R)-3-(4-broMo-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
Pharmaceutical Intermediates
On requestOn requestOn request
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Unibest Nantong cGMP Site(R)-3-cyclopentyl-3-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanenitrile
Pharmaceutical Intermediates
On requestOn requestOn request
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Unibest Taizhou GMP-like Site3-Cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile
Pharmaceutical Intermediates
On requestOn requestOn request
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Qualified Partner — East China API Works(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
Pharmaceutical Intermediates
On requestOn requestOn request
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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.