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CAS 943-73-7

2(S)-Amino-4-phenylbutanoic acid

Codes: Enalapril-073

Application context (from source-drug indications)

Cardiac and vascular disordersAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHypertensionAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHyperlipidaemiaAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilHeart diseaseAtorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilEssential hypertensionEnalapril Maleate/Folic AcidHeart failureEnalapril MaleateHypertensionEnalapril MaleateMyocardial infarctionEnalapril MaleateAngina pectorisEnalapril MaleateLeft ventricular dysfunctionEnalapril MaleateSolid tumourEnalapril Maleate

Source drugs (routes using this intermediate)

DrugTierExpiry
Atorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilTier C — Watch / trade-
Enalapril Maleate/Folic AcidTier C — Watch / trade-
Enalapril MaleateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Atorvastatin/Hydrochlorothiazide/Aspirin/EnalaprilOptimised routesteps: 5total yield: 3.9g(Enalapril-073)
(S)-Aminobutanedioic acid→Dimethyl L-aspartate hydrogen chloride→Dimethyl N-(triphenylmethyl)-L-aspartate→1-(Bromomethyl)benzene→Dimethyl 3-benzyl-N-(triphenylmethyl)-L-aspartate→(3R)-3-Benzyl-L-aspartic acid→2(S)-Amino-4-phenylbutanoic acid
Enalapril Maleate/Folic AcidOptimised routesteps: 5total yield: 3.9g(Enalapril-073)
(S)-Aminobutanedioic acid→Dimethyl L-aspartate hydrogen chloride→Dimethyl N-(triphenylmethyl)-L-aspartate→1-(Bromomethyl)benzene→Dimethyl 3-benzyl-N-(triphenylmethyl)-L-aspartate→(3R)-3-Benzyl-L-aspartic acid→2(S)-Amino-4-phenylbutanoic acid
Enalapril MaleateOptimised routesteps: 5total yield: 3.9g(Enalapril-073)
(S)-Aminobutanedioic acid→Dimethyl L-aspartate hydrogen chloride→Dimethyl N-(triphenylmethyl)-L-aspartate→1-(Bromomethyl)benzene→Dimethyl 3-benzyl-N-(triphenylmethyl)-L-aspartate→(3R)-3-Benzyl-L-aspartic acid→2(S)-Amino-4-phenylbutanoic acid

Intermediates available on this site

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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.