← Back to patent-cliff list
CAS 943856-40-4
isopropyl 3-(methoxymethoxy)pent-4-enoate
Codes: CENSA-022
Application context (from source-drug indications)
进行性核上性麻痹CensavudineFrontotemporal dementiaCensavudineAmyotrophic lateral sclerosisCensavudineAicardi综合征CensavudineHIV infectionCensavudine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Censavudine | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
5-methylpyrimidine-2,4(1H,3H)-dione→isopropyl acetate→acrylaldehyde→isopropyl 3-hydroxypent-4-enoate→isopropyl 3-(methoxymethoxy)pent-4-enoate→isopropyl 4,5-dihydroxy-3-(methoxymethoxy)pentanoate→isopropyl 5-((tert-butyldimethylsilyl)oxy)-4-hydroxy-3-(methoxymethoxy)pentanoate→isopropyl 5-((tert-butyldimethylsilyl)oxy)-3-(methoxymethoxy)-4-oxopentanoate→ethynylmagnesium bromide→isopropyl (3S,4R)-4-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxy-3-(methoxymethoxy)hex-5-ynoate→(4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-ethynyl-4-(methoxymethoxy)tetrahydrofuran-2-ol→(4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-ethynyl-4-(methoxymethoxy)tetrahydrofuran-2-yl acetate→1-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-ethynyl-4-(methoxymethoxy)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione→1-((2R,4S,5R)-5-ethynyl-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione→1-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-ethynyl-4-hydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione→(2R,3S,5R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-2-ethynyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl methanesulfonate→1-((2R,5R)-5-ethynyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.