CAS 945749-71-3

4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)benzoic acid

Codes: MOME-006

Application context (from source-drug indications)

MyelofibrosisMomelotinib DihydrochlorideMyeloproliferative neoplasmMomelotinib DihydrochlorideSplenomegalyMomelotinib DihydrochlorideAnaemiaMomelotinib DihydrochlorideVEXAS综合征Momelotinib DihydrochlorideEssential thrombocythaemiaMomelotinib Dihydrochloride

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Momelotinib Dihydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

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Momelotinib DihydrochlorideOriginator routesteps: 5total yield: 31.69 g

2,4-dichloropyrimidine→(4-(ethoxycarbonyl)phenyl)boronic acid→ethyl 4-(2-chloropyrimidin-4-yl)benzoate→4-morpholinoaniline→ethyl 4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)benzoate→4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)benzoic acid→2-aminoacetonitrile hydrochloride

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Qualified Partner — East China API Works	4-(2-(4-MorpholinophenylaMino)pyriMidin-4-yl)benzoic acid Pharmaceutical Intermediates	On request	On request	On request	—

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