← Back to patent-cliff list
CAS 95-25-0
5-chlorobenzo[d]oxazol-2(3H)-one
Codes: AZD-7986-002
Application context (from source-drug indications)
BronchiectasisBrensocatibLung diseaseBrensocatibSinusitisBrensocatibCystic fibrosisBrensocatibHepatic function declineBrensocatibRenal impairmentBrensocatib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Brensocatib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
AZD-7986→2-amino-4-chlorophenol→5-chlorobenzo[d]oxazol-2(3H)-one→5-chloro-3-methylbenzo[d]oxazol-2(3H)-one→3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazol-2(3H)-one→tert-butyl (S)-(1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbamate→tert-butyl (S)-(1-amino-3-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)-1-oxopropan-2-yl)carbamate→(S)-2-amino-3-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)propanamide→(S)-4-(tert-butoxycarbonyl)-1,4-oxazepane-2-carboxylic acid→tert-butyl (S)-2-(((S)-1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)carbamoyl)-1,4-oxazepane-4-carboxylate→(S)-methyl oxirane-2-carboxylate→methyl (S)-3-(dibenzylamino)-2-hydroxypropanoate→methyl propiolate→methyl (S,E)-3-((3-(dibenzylamino)-1-methoxy-1-oxopropan-2-yl)oxy)acrylate→methyl (S)-3-amino-2-(3-methoxy-3-oxopropoxy)propanoate→methyl (S)-5-oxo-1,4-oxazepane-2-carboxylate→4-(tert-butyl) 2-methyl (S)-5-oxo-1,4-oxazepane-2,4-dicarboxylate→4-(tert-butyl) 2-methyl (S)-1,4-oxazepane-2,4-dicarboxylate
AZD-7986→5-chlorobenzo[d]oxazol-2(3H)-one→5-chloro-3-methylbenzo[d]oxazol-2(3H)-one→tert-butyl (S)-(1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbamate→(S)-4-(tert-butoxycarbonyl)-1,4-oxazepane-2-carboxylic acid→tert-butyl (S)-2-(((S)-1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)carbamoyl)-1,4-oxazepane-4-carboxylate→methyl (chlorosulfonyl)carbamate→tert-butyl (S)-(1-cyano-2-(4-iodophenyl)ethyl)carbamate→5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-3-methylbenzo[d]oxazol-2(3H)-one→tert-butyl (S)-(1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)carbamate→(S)-2-amino-3-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)propanenitrile→3-(benzylamino)propan-1-ol→(S)-2-((benzyloxy)methyl)oxirane→(S)-3-(benzyl(3-(benzyloxy)-2-hydroxypropyl)amino)propan-1-ol→(S)-4-benzyl-2-((benzyloxy)methyl)-1,4-oxazepane→tert-butyl (S)-2-(hydroxymethyl)-1,4-oxazepane-4-carboxylate→5,5,5',5'-tetramethyl-2,2'-bi(1,3,2-dioxaborinane)
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 3-Methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3H-benzooxazol-2-one Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | (S)-4-(tert-butoxycarbonyl)-1,4-oxazepane-2-carboxylicacid Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | tert-butyl (S)-(1-cyano-2-(4-iodophenyl)ethyl)carbamate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 5-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-3-methyl-1,3-benzoxazol-2(3H)-one Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | tert-butyl (S)-(1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbamate Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.