CAS 956104-44-2

6-chloro-N-(4-methoxybenzyl)-5-(trifluoromethyl)pyridin-3-amine

Codes: APAL-005

Application context (from source-drug indications)

Castration-resistant prostate cancerApalutamideProstate cancerApalutamide

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Apalutamide	Tier A — Act now	2030

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

ApalutamideOriginator routesteps: 11total yield: /

3-(trifluoromethyl)pyridin-2-ol→5-iodo-3-(trifluoromethyl)pyridin-2-ol→2-chloro-5-iodo-3-(trifluoromethyl)pyridine→(4-methoxyphenyl)methanamine→6-chloro-N-(4-methoxybenzyl)-5-(trifluoromethyl)pyridin-3-amine→5-((4-methoxybenzyl)amino)-3-(trifluoromethyl)picolinonitrile→5-amino-3-(trifluoromethyl)picolinonitrile→5-isothiocyanato-3-(trifluoromethyl)picolinonitrile→4-((1-cyanocyclobutyl)amino)-2-fluoro-N-methylbenzamide→2,4-difluorobenzoyl chloride→2,4-difluoro-N-methylbenzamide→2-fluoro-4-((4-methoxybenzyl)amino)-N-methylbenzamide→4-amino-2-fluoro-N-methylbenzamide→cyclobutanone

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	5-Amino-3-(trifluoromethyl)picolinonitrile Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	N-Boc-1-aminocyclobutanecarboxylic acid Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	1-amino-N-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]Cyclobutanecarboxamide Pharmaceutical Intermediates	On request	On request	On request	—

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