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CAS 957215-03-1
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 2-[N-(3,3-diphenylpropyl)-N-methylamino]-1,1-dimethylethyl methyl diester oxalate
Codes: Lercanidipine Hydrochloride-028
Application context (from source-drug indications)
Essential hypertensionValsartan/Lercanidipine HydrochlorideHypertensionLercanidipine Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Valsartan/Lercanidipine Hydrochloride | Tier C — Watch / trade | - |
| Lercanidipine Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid→5-(Chlorocarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid methyl ester→2-Methyl-1-(methylamino)propan-2-ol p-toluenesulfonate→2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 1,1-dimethyl-2-(methylamino)ethyl methyl ester→3,3-Diphenylpropan-1-ol→4-Methylbenzenesulfonic acid 3,3-diphenylpropyl ester→1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 2-[N-(3,3-diphenylpropyl)-N-methylamino]-1,1-dimethylethyl methyl diester oxalate
(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid→5-(Chlorocarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid methyl ester→2-Methyl-1-(methylamino)propan-2-ol p-toluenesulfonate→2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 1,1-dimethyl-2-(methylamino)ethyl methyl ester→3,3-Diphenylpropan-1-ol→4-Methylbenzenesulfonic acid 3,3-diphenylpropyl ester→1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 2-[N-(3,3-diphenylpropyl)-N-methylamino]-1,1-dimethylethyl methyl diester oxalate
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