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CAS 96-49-1
1,3-Dioxolan-2-one1,3-dioxolan-2-one
Codes: Tamsulosin Hydrochloride-011, ADEF-004
Application context (from source-drug indications)
Erectile dysfunctionTadalafil/TamsulosinBenign prostatic hyperplasiaTadalafil/TamsulosinLower urinary tract symptomsSolifenacin Succinate/Tamsulosin HydrochlorideBenign prostatic hyperplasiaSolifenacin Succinate/Tamsulosin HydrochlorideOveractive bladderSolifenacin Succinate/Tamsulosin HydrochlorideDrug-related adverse effects and reactionsSolifenacin Succinate/Tamsulosin HydrochlorideBladder neck obstructionSolifenacin Succinate/Tamsulosin HydrochlorideBenign prostatic hyperplasiaDutasteride/Tamsulosin HydrochlorideBenign prostatic hyperplasiaTamsulosin HydrochlorideUrinary tract infectionTamsulosin HydrochlorideUrinary retentionTamsulosin HydrochlorideInguinal herniaTamsulosin HydrochlorideVoiding dysfunctionTamsulosin HydrochlorideLower urinary tract symptomsTamsulosin HydrochlorideHepatitis BAdefovir DipivoxilChronic hepatitis BAdefovir DipivoxilHIV infectionAdefovir DipivoxilLiver transplant rejectionAdefovir DipivoxilHepatitisAdefovir Dipivoxil巨细胞病毒感染Adefovir Dipivoxil
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tadalafil/Tamsulosin | Tier C — Watch / trade | - |
| Solifenacin Succinate/Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Dutasteride/Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Adefovir Dipivoxil | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-(4-Methoxyphenyl)-2-propanone→(R)-(-)-1-Phenylethylamine→(2R)-1-(4-Methoxyphenyl)-N-[(1R)-1-phenylethyl]propan-2-amine hydrochloride→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide→5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide hydrochloride→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide hydrochloride→(2-Ethoxyphenoxy)acetaldehyde→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide→1-(2-Bromoethoxy)-2-ethoxybenzene→1-Hydroxy-2-ethoxybenzene→1,3-Dioxolan-2-one→2-(2-Ethoxyphenoxy)ethanol
1,3-Dioxolan-2-one→1-Hydroxy-2-ethoxybenzene→2-(2-Ethoxyphenoxy)ethanol→2-(2-Ethoxyphenoxy)ethyl mesylate→1,2-Dihydroxyethane→1,2-Dimethylsulfonyloxyethane→5-(2-Aminopropyl)-N-tert-butyl-2-methoxybenzene-1-sulfonamide→N-tert-Butyl-2-methoxy-5-(2-oxopropyl)benzene-1-sulfonamide→(±)-N-tert-Butyl-5-(2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl)-2-methoxybenzene-1-sulfonamide→(±)-5-(2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl)-2-methoxybenzene-1-sulfonamide
Solifenacin Succinate/Tamsulosin HydrochlorideOptimised routesteps: 9total yield: 50.8g(Tamsulosin (Free))
1-(4-Methoxyphenyl)-2-propanone→(R)-(-)-1-Phenylethylamine→(2R)-1-(4-Methoxyphenyl)-N-[(1R)-1-phenylethyl]propan-2-amine hydrochloride→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide→5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide hydrochloride→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide hydrochloride→(2-Ethoxyphenoxy)acetaldehyde→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide→1-(2-Bromoethoxy)-2-ethoxybenzene→1-Hydroxy-2-ethoxybenzene→1,3-Dioxolan-2-one→2-(2-Ethoxyphenoxy)ethanol
Solifenacin Succinate/Tamsulosin HydrochlorideOptimised routesteps: 7total yield: 165g(Racemic Tamsulosinc (Free))
1,3-Dioxolan-2-one→1-Hydroxy-2-ethoxybenzene→2-(2-Ethoxyphenoxy)ethanol→2-(2-Ethoxyphenoxy)ethyl mesylate→1,2-Dihydroxyethane→1,2-Dimethylsulfonyloxyethane→5-(2-Aminopropyl)-N-tert-butyl-2-methoxybenzene-1-sulfonamide→N-tert-Butyl-2-methoxy-5-(2-oxopropyl)benzene-1-sulfonamide→(±)-N-tert-Butyl-5-(2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl)-2-methoxybenzene-1-sulfonamide→(±)-5-(2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl)-2-methoxybenzene-1-sulfonamide
1-(4-Methoxyphenyl)-2-propanone→(R)-(-)-1-Phenylethylamine→(2R)-1-(4-Methoxyphenyl)-N-[(1R)-1-phenylethyl]propan-2-amine hydrochloride→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide→5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide hydrochloride→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide hydrochloride→(2-Ethoxyphenoxy)acetaldehyde→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide→1-(2-Bromoethoxy)-2-ethoxybenzene→1-Hydroxy-2-ethoxybenzene→1,3-Dioxolan-2-one→2-(2-Ethoxyphenoxy)ethanol
Dutasteride/Tamsulosin HydrochlorideOptimised routesteps: 7total yield: 165g(Racemic Tamsulosinc (Free))
1,3-Dioxolan-2-one→1-Hydroxy-2-ethoxybenzene→2-(2-Ethoxyphenoxy)ethanol→2-(2-Ethoxyphenoxy)ethyl mesylate→1,2-Dihydroxyethane→1,2-Dimethylsulfonyloxyethane→5-(2-Aminopropyl)-N-tert-butyl-2-methoxybenzene-1-sulfonamide→N-tert-Butyl-2-methoxy-5-(2-oxopropyl)benzene-1-sulfonamide→(±)-N-tert-Butyl-5-(2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl)-2-methoxybenzene-1-sulfonamide→(±)-5-(2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl)-2-methoxybenzene-1-sulfonamide
1-(4-Methoxyphenyl)-2-propanone→(R)-(-)-1-Phenylethylamine→(2R)-1-(4-Methoxyphenyl)-N-[(1R)-1-phenylethyl]propan-2-amine hydrochloride→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide→5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide hydrochloride→2-Methoxy-5-[(2R)-2-[[(1R)-1-phenylethyl]amino]propyl]benzenesulfonamide hydrochloride→(2-Ethoxyphenoxy)acetaldehyde→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide→1-(2-Bromoethoxy)-2-ethoxybenzene→1-Hydroxy-2-ethoxybenzene→1,3-Dioxolan-2-one→2-(2-Ethoxyphenoxy)ethanol
1,3-Dioxolan-2-one→1-Hydroxy-2-ethoxybenzene→2-(2-Ethoxyphenoxy)ethanol→2-(2-Ethoxyphenoxy)ethyl mesylate→1,2-Dihydroxyethane→1,2-Dimethylsulfonyloxyethane→5-(2-Aminopropyl)-N-tert-butyl-2-methoxybenzene-1-sulfonamide→N-tert-Butyl-2-methoxy-5-(2-oxopropyl)benzene-1-sulfonamide→(±)-N-tert-Butyl-5-(2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl)-2-methoxybenzene-1-sulfonamide→(±)-5-(2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl)-2-methoxybenzene-1-sulfonamide
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