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CAS 96202-57-2
6-chloro-5-fluoroindoline-2,3-dione
Codes: CIPARG-026
Application context (from source-drug indications)
Falciparum malariaCipargaminPlasmodium infectionCipargamin
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Cipargamin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
5-chloroindoline-2,3-dione→6-chloro-5-fluoroindoline-2,3-dione→6-chloro-5-fluoro-3-hydroxy-3-(2-oxopropyl)indolin-2-one→6-chloro-5-fluoro-3-hydroxy-3-((2-methyl-1,3-dioxolan-2-yl)methyl)indolin-2-one→1-(6-chloro-5-fluoro-1H-indol-3-yl)propan-2-one→(S)-1-(6-chloro-5-fluoro-1H-indol-3-yl)propan-2-amine (7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid→(3R,3'S)-5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one (7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid→(3R,3'S)-5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyrido[3,4-b]indol]-2-one
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