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CAS 98-79-3
(S)-5-oxopyrrolidine-2-carboxylic acid
Codes: ERTU-018, SAXA-001
Application context (from source-drug indications)
Type 2 diabetesErtugliflozinMitral regurgitationErtugliflozinLeft ventricular dysfunctionErtugliflozinHeart failureErtugliflozinAtherosclerosisErtugliflozinInsulin resistanceErtugliflozinType 2 diabetesDapagliflozin Propanediol Monohydrate/Saxagliptin HydrochlorideType 2 diabetesSaxagliptin HydrateHypoglycaemiaSaxagliptin HydrateType 1 diabetesSaxagliptin HydrateDiabetesSaxagliptin Hydrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ertugliflozin | Tier C — Watch / trade | - |
| Dapagliflozin Propanediol Monohydrate/Saxagliptin Hydrochloride | Tier C — Watch / trade | - |
| Saxagliptin Hydrate | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene→(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one→(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol→((2R,3R,4S,5R,6S)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-methoxy-3,4,5-tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methanol→(2S,3R,4S,5R,6S)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-methoxy-3,4,5-tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2-carbaldehyde→(2S,3R,4S,5S)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6,6-bis(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol→(S)-5-oxopyrrolidine-2-carboxylic acid
Dapagliflozin Propanediol Monohydrate/Saxagliptin HydrochlorideOriginator routesteps: 11total yield: /
(S)-5-oxopyrrolidine-2-carboxylic acid→(S)-ethyl 5-oxopyrrolidine-2-carboxylate→1-(tert-butyl) 2-ethyl (S)-5-oxopyrrolidine-1,2-dicarboxylate→1-(tert-butyl) 2-ethyl (S)-2,3-dihydro-1H-pyrrole-1,2-dicarboxylate→(S)-1-(tert-butoxycarbonyl)-2,3-dihydro-1H-pyrrole-2-carboxylic acid→tert-butyl (S)-2-carbamoyl-2,3-dihydro-1H-pyrrole-1-carboxylate→tert-butyl (1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hexane-2-carboxylate→(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate→tert-butyl ((S)-2-((1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)carbamate→(1R,3r,5R,7S)-3-((S)-1-((tert-butoxycarbonyl)amino)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl 2,2,2-trifluoroacetate→tert-butyl ((S)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)carbamate→(S)-2-((tert-butoxycarbonyl)amino)-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→(3s,5s,7s)-1-bromoadamantane→2,2,7,7-tetramethyl-4-((trimethylsilyl)oxy)-3,6-dioxa-2,7-disilaoct-4-ene→2-((3r,5r,7r)-adamantan-1-yl)-2-hydroxyacetic acid→methyl 2-((3r,5r,7r)-adamantan-1-yl)-2-hydroxyacetate→methyl 2-((3r,5r,7r)-adamantan-1-yl)-2-oxoacetate→methyl 2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoacetate→2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoacetic acid→(S)-2-amino-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→methyl 2,2,2-trichloroacetate→((2,2-dichloro-1-methoxyvinyl)oxy)trimethylsilane→methyl 2-((3r,5r,7r)-adamantan-1-yl)-2,2-dichloroacetate→methyl 2,2-dichloro-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetate→2,2-dichloro-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→2-((3r,5r,7r)-adamantan-1-yl)acetic acid→2-((3r,5r,7r)-adamantan-1-yl)-2-bromoacetic acid→2-bromo-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→2-amino-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→2-((tert-butoxycarbonyl)amino)-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid
(S)-5-oxopyrrolidine-2-carboxylic acid→(S)-ethyl 5-oxopyrrolidine-2-carboxylate→1-(tert-butyl) 2-ethyl (S)-5-oxopyrrolidine-1,2-dicarboxylate→1-(tert-butyl) 2-ethyl (S)-2,3-dihydro-1H-pyrrole-1,2-dicarboxylate→(S)-1-(tert-butoxycarbonyl)-2,3-dihydro-1H-pyrrole-2-carboxylic acid→tert-butyl (S)-2-carbamoyl-2,3-dihydro-1H-pyrrole-1-carboxylate→tert-butyl (1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hexane-2-carboxylate→(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate→tert-butyl ((S)-2-((1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)carbamate→(1R,3r,5R,7S)-3-((S)-1-((tert-butoxycarbonyl)amino)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl 2,2,2-trifluoroacetate→tert-butyl ((S)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)carbamate→(S)-2-((tert-butoxycarbonyl)amino)-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→(3s,5s,7s)-1-bromoadamantane→2,2,7,7-tetramethyl-4-((trimethylsilyl)oxy)-3,6-dioxa-2,7-disilaoct-4-ene→2-((3r,5r,7r)-adamantan-1-yl)-2-hydroxyacetic acid→methyl 2-((3r,5r,7r)-adamantan-1-yl)-2-hydroxyacetate→methyl 2-((3r,5r,7r)-adamantan-1-yl)-2-oxoacetate→methyl 2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoacetate→2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoacetic acid→(S)-2-amino-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→methyl 2,2,2-trichloroacetate→((2,2-dichloro-1-methoxyvinyl)oxy)trimethylsilane→methyl 2-((3r,5r,7r)-adamantan-1-yl)-2,2-dichloroacetate→methyl 2,2-dichloro-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetate→2,2-dichloro-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→2-((3r,5r,7r)-adamantan-1-yl)acetic acid→2-((3r,5r,7r)-adamantan-1-yl)-2-bromoacetic acid→2-bromo-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→2-amino-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→2-((tert-butoxycarbonyl)amino)-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | 2-((benzyloxy)(4-ethoxyphenyl)methyl)-4-bromo-1-chlorobenzene Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | (2R, 3S.4S)-2, 3, 4-tris(benzyloxy)-4-((R)-4-((benzyloxy)meth yl)-2, 2-dimeth yl-1, 3- dioxolan-4-yl)-1-(4-methylDiDerazin-1-yl)butan-1-one Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.