CAS 98-84-0

1-phenylethan-1-amine

Codes: SITAF-031, PEME-027

Application context (from source-drug indications)

CystitisSitafloxacin HydrateSinusitisSitafloxacin HydrateTonsillitisSitafloxacin HydratePneumoniaSitafloxacin HydrateCervicitisSitafloxacin HydratePericoronitisSitafloxacin HydrateNon-small cell lung cancerPemetrexed Disodium Hydrate间皮组织肿瘤Pemetrexed Disodium Hydrate胸膜孤立性纤维瘤Pemetrexed Disodium HydrateBladder cancerPemetrexed Disodium HydrateUrothelial carcinomaPemetrexed Disodium HydrateSolid tumourPemetrexed Disodium Hydrate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Sitafloxacin Hydrate	Tier C — Watch / trade	-
Pemetrexed Disodium Hydrate	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Sitafloxacin HydrateOptimised routesteps: 8total yield: /

tert-butyl ((1R,2S)-2-fluorocyclopropyl)carbamate→(1R,2S)-2-fluorocyclopropan-1-amine hydrochloride→1-phenylethan-1-amine→N-(1-phenylethyl)ethenamine→(1-phenylethyl)(vinyl)carbamic chloride→benzyl (1-phenylethyl)(vinyl)carbamate→benzyl (2-fluorocyclopropyl)(1-phenylethyl)carbamate→2-fluorocyclopropan-1-amine hydrochloride→(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl carbonochloridate→(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ((1R,2S)-2-fluorocyclopropyl)carbamate

Pemetrexed Disodium HydrateOptimised routesteps: 9total yield: /

guanidine→1-phenylethan-1-amine→methyl carbonochloridate→methyl (1-phenylethyl)carbamate→(E)-1-bromobut-2-ene→methyl (E)-but-2-en-1-yl(1-phenylethyl)carbamate→(E)-N-(1-phenylethyl)but-2-en-1-amine→dimethyl malonate→methyl (E)-3-(but-2-en-1-yl(1-phenylethyl)amino)-3-oxopropanoate→methyl 2-oxo-1-(1-phenylethyl)-4-vinylpyrrolidine-3-carboxylate→methyl 1-(1-phenylethyl)-2-thioxo-4-vinylpyrrolidine-3-carboxylate→2-amino-7-(1-phenylethyl)-5-vinyl-3,5,6,7-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one→diethyl (4-iodobenzoyl)-L-glutamate→diethyl (4-(2-(2-amino-4-oxo-7-(1-phenylethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamate

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Nantong cGMP Site	Carbamic acid, (7S)-5-azaspiro[2.4]hept-7-yl-, 1,1-dimethylethyl ester (9CI) Pharmaceutical Intermediates	On request	On request	On request	—

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