CAS 98475-07-1

methyl 2-(bromomethyl)-3-nitrobenzoate

Codes: LENA-003

Application context (from source-drug indications)

Marginal zone B-cell lymphomaLenalidomideFollicular lymphomaLenalidomideAdult T-cell leukaemia/lymphomaLenalidomideMantle cell lymphomaLenalidomideMyelodysplastic syndromeLenalidomideMultiple myelomaLenalidomide

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Lenalidomide	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

LenalidomideOriginator routesteps: 5total yield: 0.46 g

methyl 2-methyl-3-nitrobenzoate→1-bromopyrrolidine-2,5-dione→methyl 2-(bromomethyl)-3-nitrobenzoate→(tert-butoxycarbonyl)-L-glutamine→(R)-2-((tert-butoxycarbonyl)amino)-5-(4-nitro-1-oxoisoindolin-2-yl)-5-oxopentanoic acid→(R)-2-amino-5-(4-nitro-1-oxoisoindolin-2-yl)-5-oxopentanoic acid→3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione

LenalidomideOptimised routesteps: 5total yield: 1.12 g

methyl 2-(bromomethyl)-3-nitrobenzoate→4-nitroisoindolin-1-one→4-aminoisoindolin-1-one→dimethyl 2-bromopentanedioate→dimethyl 2-(4-amino-1-oxoisoindolin-2-yl)pentanedioate→glutaric acid

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Qualified Partner — East China API Works	methyl 2-(bromomethyl)-3-nitrobenzoate Pharmaceutical Intermediates	On request	On request	On request	—

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