Tipiracil Hydrochloride

Tier C — Watch / trade

Taiho Pharmaceutical Co., Ltd.

Originator

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：TYMP

Indications (approved)：Oesophageal cancer, Gastric cancer, Adenocarcinoma

Regional status

Phase II

2021-06-16

China

Japan

Synthetic routes & intermediates2 routes

Originator routes × 1Optimised (non-patent) × 1Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 5 · Total yield 18 g (Tipiracil Hydrochloride)

Tipiracil183204-74-2TIPIRA-00114527-26-5TIPIRA-002638-07-3TIPIRA-0031871659-70-9TIPIRA-004847661-75-0TIPIRA-00573742-45-7TIPIRA-0067544-75-4Tipiracil Hydrochloride183204-72-0API · Tipiracil Hydrochloride

Code	CAS No.	Intermediate
Tipiracil	183204-74-2	5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione
TIPIRA-001	14527-26-5 Available	methyl carbamimidothioate sulfate
TIPIRA-002	638-07-3	ethyl 4-chloro-3-oxobutanoate
TIPIRA-003	1871659-70-9	6-(chloromethyl)-2-(methylthio)pyrimidin-4(3H)-one
TIPIRA-004	847661-75-0	5-chloro-6-(chloromethyl)-2-(methylthio)pyrimidin-4(3H)-one
TIPIRA-005	73742-45-7	5-chloro-6-(chloromethyl)pyrimidine-2,4(1H,3H)-dione
TIPIRA-006	7544-75-4	pyrrolidin-2-imine hydrochloride
Tipiracil Hydrochloride	183204-72-0	5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione hydrochloride

OptimisedRoute 2Steps 2 · Total yield 2.68 g (Tipiracil)

Tipiracil183204-74-2TIPIRA-00573742-45-7TIPIRA-00718592-13-7TIPIRA-008872-34-4API · Tipiracil Hydrochloride

Code	CAS No.	Intermediate
Tipiracil	183204-74-2	5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione
TIPIRA-005	73742-45-7	5-chloro-6-(chloromethyl)pyrimidine-2,4(1H,3H)-dione
TIPIRA-007	18592-13-7	6-(chloromethyl)pyrimidine-2,4(1H,3H)-dione
TIPIRA-008	872-34-4	pyrrolidin-2-imine

Frequently asked questions

What are the approved indications of Tipiracil Hydrochloride?

Approved indications include: Oesophageal cancer, Gastric cancer, Adenocarcinoma.

When does the Tipiracil Hydrochloride patent expire?

No public expiry year is available for Tipiracil Hydrochloride yet; this page updates once verified.

How many synthesis routes are recorded for Tipiracil Hydrochloride?

2 synthesis routes are recorded; the shortest is 2 steps with 2.68 g (Tipiracil) total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Tipiracil Hydrochloride intermediates?

1 intermediate CAS of Tipiracil Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Tipiracil Hydrochloride intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-10-06