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CAS 183204-74-2
5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione
Codes: Tipiracil
Application context (from source-drug indications)
Oesophageal cancerTipiracil HydrochlorideGastric cancerTipiracil HydrochlorideAdenocarcinomaTipiracil Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tipiracil Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione→methyl carbamimidothioate sulfate→ethyl 4-chloro-3-oxobutanoate→6-(chloromethyl)-2-(methylthio)pyrimidin-4(3H)-one→5-chloro-6-(chloromethyl)-2-(methylthio)pyrimidin-4(3H)-one→5-chloro-6-(chloromethyl)pyrimidine-2,4(1H,3H)-dione→pyrrolidin-2-imine hydrochloride→5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione hydrochloride
5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione→5-chloro-6-(chloromethyl)pyrimidine-2,4(1H,3H)-dione→6-(chloromethyl)pyrimidine-2,4(1H,3H)-dione→pyrrolidin-2-imine
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