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CAS 115290-81-8
(R)-3-(methylamino)-1-phenylpropan-1-ol(1R)-3-(Methylamino)-1-phenylpropan-1-ol
Codes: R-fluoxetine-011, (V)263642-1-a, (VI)263642-7-a, (IXb)263642-13-a
Application context (from source-drug indications)
分离性焦虑R-fluoxetineAnxietyR-fluoxetineAnxiety disorderR-fluoxetine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| R-fluoxetine | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-2-amino-3-methylbutanoic acid→(tert-butoxycarbonyl)-L-valine→(R)-1-phenylethan-1-amine→tert-butyl ((S)-3-methyl-1-oxo-1-(((R)-1-phenylethyl)amino)butan-2-yl)carbamate→(S)-2-amino-3-methyl-N-((R)-1-phenylethyl)butanamide→(S)-3-methyl-N1-((R)-1-phenylethyl)butane-1,2-diamine→(S)-4-isopropyl-1-((R)-1-phenylethyl)imidazolidin-2-one→(S)-3-acetyl-4-isopropyl-1-((R)-1-phenylethyl)imidazolidin-2-one→(S)-3-((R)-3-hydroxy-3-phenylpropanoyl)-4-isopropyl-1-((R)-1-phenylethyl)imidazolidin-2-one→(R)-3-hydroxy-N-methyl-3-phenylpropanamide→(R)-3-(methylamino)-1-phenylpropan-1-ol→1-fluoro-4-(trifluoromethyl)benzene→R-fluoxetine
1-Phenylethan-1-one→Benzylmethylamine→3-[benzyl(methyl)amino]-1-phenylpropan-1-one→(1R)-3-[Benzyl(methyl)amino]-1-phenylpropan-1-ol→(1R)-3-(Methylamino)-1-phenylpropan-1-ol→1-Chloro-4-(trifluoromethyl)benzene
3-Oxo-3-phenylpropanenitrile→(3R)-3-Hydroxy-3-phenylpropanenitrile→3-Hydroxy-3-phenylpropanenitrile→(1R)-3-Amino-1-phenylpropan-1-ol→Carbonochloridic acid ethyl ester→Carbonochloridic acid methyl ester→Ethyl [(3R)-3-hydroxy-3-phenylpropyl]carbamate→Methyl [(3R)-3-hydroxy-3-phenylpropyl]carbamate→(1R)-3-(Methylamino)-1-phenylpropan-1-ol→1-Chloro-4-(trifluoromethyl)benzene→(3R)-3-Phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine hydrochloride→Methyl [(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]carbamate→Benzaldehyde→Ethynamine
3-Phenyl-2(E)-propenal→1,1-Diphenylmethylamine→1,1-Diphenyl-N-[(1E,2E)-3-phenylprop-2-en-1-ylidene]methanamine→4,4,4',4',5,5,5',5'-Octamethyl-2,2'-bi-1,3,2-dioxaborolane→1,1-Diphenyl-N-[(1E)-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propylidene]methanamine→1,1-Diphenyl-N-[(1E,3R)-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propylidene]methanamine→Aminomethane→N-[(1E)-3-Phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propylidene]methanamine→N-[(1E,3R)-3-Phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propylidene]methanamine→N-Methyl-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propan-1-amine→(3R)-N-Methyl-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propan-1-amine→(+/-)-n-Methyl-3-hydroxy-3-phenylpropylamine→(1R)-3-(Methylamino)-1-phenylpropan-1-ol→Sodium 3-(methylamino)-1-phenylpropan-1-olate→Sodium (1R)-3-(methylamino)-1-phenylpropan-1-olate→1-Chloro-4-(trifluoromethyl)benzene→(+/-)-N-Methyl-3-phenyl-[3-[4-(trifluoromethyl)phenoxy]propylamine]
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