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CAS 33872-80-9
o-tolylmagnesium chloride
Codes: FOSNE-002
Application context (from source-drug indications)
Chemotherapy-induced nausea and vomitingFosnetupitant
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Fosnetupitant | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
6-(4-methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide→FOSNE-008→methyl (6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbamate→N-methyl-6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine→2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoyl chloride→FOSNE-012→di-tert-butyl (chloromethyl) phosphate→FOSNE-014→2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoic acid→FOSNE-016→FOSNE-017→FOSNE-018→FOSNE-019→Fosnetupitant→6-chloronicotinic acid→o-tolylmagnesium chloride→FOSNE-003→FOSNE-004→FOSNE-005→1-methylpiperazine
Intermediates available on this site
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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.