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CAS 342417-04-3
N-(tert-butyl)-6-chloro-4-(o-tolyl)nicotinamide
Codes: NETUP-005
Application context (from source-drug indications)
Chemotherapy-induced nausea and vomitingNetupitantNeoplasmNetupitant
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Netupitant | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
6-chloronicotinic acid→6-chloronicotinoyl chloride→N-(tert-butyl)-6-chloronicotinamide→o-tolylmagnesium chloride→N-(tert-butyl)-6-chloro-4-(o-tolyl)nicotinamide→N-(tert-butyl)-6-(4-methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide→6-(4-methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide→methyl (6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbamate→N-methyl-6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine→2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoyl chloride
Intermediates available on this site
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