Netupitant
Tier C — Watch / tradeNetupitant
Targets：NK1R
Indications (approved)：Chemotherapy-induced nausea and vomiting, Neoplasm
Regional status
Synthetic routes & intermediates2 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| NETUP-001 | 5326-23-8 | 6-chloronicotinic acid |
| NETUP-002 | 58757-38-3 | 6-chloronicotinoyl chloride |
| NETUP-003 | 115309-58-5 | N-(tert-butyl)-6-chloronicotinamide |
| NETUP-004 | 33872-80-9 | o-tolylmagnesium chloride |
| NETUP-005 | 342417-04-3 | N-(tert-butyl)-6-chloro-4-(o-tolyl)nicotinamide |
| NETUP-006 | 881743-64-2 | N-(tert-butyl)-6-(4-methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide |
| NETUP-007 | 342417-01-0 | 6-(4-methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide |
| NETUP-008 | 342417-02-1 | methyl (6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbamate |
| NETUP-009 | 290297-25-5 | N-methyl-6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine |
| NETUP-010 | 289686-69-7Available | 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoyl chloride |
| Code | CAS No. | Intermediate |
|---|---|---|
| NETUP-011 | 4548-45-2 | 2-chloro-5-nitropyridine |
| NETUP-012 | 55403-34-4 | 1-methyl-4-(5-nitropyridin-2-yl)piperazine |
| NETUP-013 | 55403-35-5 | 6-(4-methylpiperazin-1-yl)pyridin-3-amine |
| NETUP-014 | 290297-21-1 | N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)pivalamide |
| NETUP-015 | 290297-22-2 | N-(4-iodo-6-(4-methylpiperazin-1-yl)pyridin-3-yl)pivalamide |
| NETUP-016 | 16419-60-6 | o-tolylboronic acid |
| NETUP-017 | 290297-23-3 | N-(6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)pivalamide |
| NETUP-018 | 290297-24-4 | 6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine |
Frequently asked questions
What are the approved indications of Netupitant?
Approved indications include: Chemotherapy-induced nausea and vomiting, Neoplasm.
When does the Netupitant patent expire?
No public expiry year is available for Netupitant yet; this page updates once verified.
How many synthesis routes are recorded for Netupitant?
2 synthesis routes are recorded; the shortest is 8 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Netupitant intermediates?
1 intermediate CAS of Netupitant are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Netupitant intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-09