CAS 4548-45-2

2-chloro-5-nitropyridine

Codes: CB-103-002, NETUP-011

Application context (from source-drug indications)

Adenoid cystic carcinomaLimantrafinLeukaemiaLimantrafinAcute lymphoblastic leukaemiaLimantrafinBreast cancerLimantrafinSolid tumourLimantrafinHaematological malignancyLimantrafinChemotherapy-induced nausea and vomitingNetupitantNeoplasmNetupitant

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Limantrafin	Tier C — Watch / trade	-
Netupitant	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

LimantrafinOptimised routesteps: 2total yield: /

4-(tert-butyl)phenol→2-chloro-5-nitropyridine→2-(4-(tert-butyl)phenoxy)-5-nitropyridine→3-Pyridinamine, 6-[4-(1,1-dimethylethyl)phenoxy]-

NetupitantOptimised routesteps: 8total yield: 31.6 g

2-chloro-5-nitropyridine→1-methyl-4-(5-nitropyridin-2-yl)piperazine→6-(4-methylpiperazin-1-yl)pyridin-3-amine→N-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)pivalamide→N-(4-iodo-6-(4-methylpiperazin-1-yl)pyridin-3-yl)pivalamide→o-tolylboronic acid→N-(6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)pivalamide→6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine

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