Tiagabine Hydrochloride
Tier C — Watch / tradeTiagabine Hydrochloride
Targets：GAT1
Brand：Tiabex, Gabitril
Indications (approved)：Epilepsy, Seizure
Regional status
Synthetic routes & intermediates4 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| TIAG-001 | 5834-16-2 | 3-methylthiophene-2-carbaldehyde |
| TIAG-002 | 14282-76-9 | 2-bromo-3-methylthiophene |
| TIAG-003 | 148319-25-9 | bis(3-methylthiophen-2-yl)methanol |
| TIAG-004 | 30717-55-6 | bis(3-methylthiophen-2-yl)methanone |
| TIAG-005 | 4333-56-6 | bromocyclopropane |
| TIAG-006 | 148319-26-0 | cyclopropylbis(3-methylthiophen-2-yl)methanol |
| TIAG-007 | 109857-81-0 | 2,2'-(4-bromobut-1-ene-1,1-diyl)bis(3-methylthiophene) |
| TIAG-008 | 25137-01-3 | ethyl (R)-piperidine-3-carboxylate |
| TIAG-009 | 145821-58-5 | ethyl (R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylate |
| TIAG-010 | 2969-81-5 | ethyl 4-bromobutanoate |
| Code | CAS No. | Intermediate |
|---|---|---|
| TIAG-011 | 53374-61-1 | 2-bromo-5-chloro-3-methylthiophene |
| TIAG-012 | - | (5-chloro-3-methylthiophen-2-yl)(3-methylthiophen-2-yl)methanol |
| TIAG-013 | 157925-13-8 | (5-chloro-3-methylthiophen-2-yl)(3-methylthiophen-2-yl)methanone |
| TIAG-014 | 157925-14-9 | (5-methoxy-3-methylthiophen-2-yl)(3-methylthiophen-2-yl)methanone |
| TIAG-015 | 157925-15-0 | cyclopropyl(5-methoxy-3-methylthiophen-2-yl)(3-methylthiophen-2-yl)methanol |
| TIAG-016 | 157925-16-1 | (Z)-5-(4-bromo-1-(3-methylthiophen-2-yl)butylidene)-4-methylthiophen-2(5H)-one |
| TIAG-017 | 157925-17-2 | ethyl (R,Z)-1-(4-(3-methyl-5-oxothiophen-2(5H)-ylidene)-4-(3-methylthiophen-2-yl)butyl)piperidine-3-carboxylate |
| TIAG-001 | 5834-16-2 | 3-methylthiophene-2-carbaldehyde |
| TIAG-005 | 4333-56-6 | bromocyclopropane |
| TIAG-008 | 25137-01-3 | ethyl (R)-piperidine-3-carboxylate |
| Code | CAS No. | Intermediate |
|---|---|---|
| TIAG-002 | 14282-76-9 | 2-bromo-3-methylthiophene |
| TIAG-018 | 96-48-0 | dihydrofuran-2(3H)-one |
| TIAG-019 | 847233-26-5 | 1,1-bis(3-methylthiophen-2-yl)butane-1,4-diol |
| TIAG-020 | 847233-13-0 | 4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl methanesulfonate |
| TIAG-021 | 495-19-2 | methyl 1,2,5,6-tetrahydropyridine-3-carboxylate |
| TIAG-022 | 1499189-55-7 | methyl 1-(4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl)-1,2,5,6-tetrahydropyridine-3-carboxylate |
| TIAG-023 | 148319-38-4 | 1-(4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid |
| TIAG-024 | - | - |
| Code | CAS No. | Intermediate |
|---|---|---|
| TIAG-004 | 30717-55-6 | bis(3-methylthiophen-2-yl)methanone |
| TIAG-008 | 25137-01-3 | ethyl (R)-piperidine-3-carboxylate |
| TIAG-009 | 145821-58-5 | ethyl (R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylate |
| TIAG-025 | 42843-94-7 | ethyl 3-(bromotriphenyl-l5-phosphanyl)propanoate |
| TIAG-026 | 1417220-54-2 | ethyl 4,4-bis(3-methylthiophen-2-yl)but-3-enoate |
| TIAG-027 | 1417220-55-3 | 4,4-bis(3-methylthiophen-2-yl)but-3-enoic acid |
| TIAG-028 | 1417220-56-4 | 4,4-bis(3-methylthiophen-2-yl)but-3-enoyl chloride |
| TIAG-029 | 1417220-57-5 | ethyl (R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enoyl)piperidine-3-carboxylate |
Frequently asked questions
What are the approved indications of Tiagabine Hydrochloride?
Approved indications include: Epilepsy, Seizure.
When does the Tiagabine Hydrochloride patent expire?
No public expiry year is available for Tiagabine Hydrochloride yet; this page updates once verified.
How many synthesis routes are recorded for Tiagabine Hydrochloride?
4 synthesis routes are recorded; the shortest is 6 steps with 93.00 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Tiagabine Hydrochloride intermediates?
All intermediates in Tiagabine Hydrochloride routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Tiagabine Hydrochloride intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-04