PT-2385

Tier C — Watch / trade

PT-2385

Peloton Therapeutics Inc

Originator

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：EPAS1

Indications (approved)：von Hippel-Lindau syndrome, Sarcoma, Renal cell carcinoma, 肾肿瘤, Glioblastoma

Regional status

Phase II

2017-04-24

China

Japan

Synthetic routes & intermediates2 routes

Originator routes × 0Optimised (non-patent) × 1Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 2Steps 6 · Total yield 2.15 g

PT-2385-014433939-27-6PT-2385-0151672665-31-4PT-2385-0161672665-51-8PT-2385-0171672665-53-0PT-2385-018109-73-9PT-2385-0192007115-81-1API · PT-2385

Code	CAS No.	Intermediate
PT-2385-014	433939-27-6	3-bromo-5-fluorophenol
PT-2385-015	1672665-31-4	4-fluoro-7-(methylsulfonyl)-2,3-dihydrospiro[indene-1,2'-[1,3]dioxolane]
PT-2385-016	1672665-51-8	4-(3-bromo-5-fluorophenoxy)-7-(methylsulfonyl)-2,3-dihydrospiro[indene-1,2'-[1,3]dioxolane]
PT-2385-017	1672665-53-0	3-fluoro-5-((7-(methylsulfonyl)-2,3-dihydrospiro[indene-1,2'-[1,3]dioxolan]-4-yl)oxy)benzonitrile
PT-2385-018	109-73-9	butan-1-amine
PT-2385-019	2007115-81-1	(E)-3-((1-(butylimino)-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile

ProcessRoute 1Steps 10 · Total yield 11.93 kg

PT-2385-0011073-72-9PT-2385-00267868-84-2PT-2385-0032033-24-1PT-2385-0042004756-76-5PT-2385-0051672665-65-4PT-2385-00664248-63-1PT-2385-0071672665-67-6PT-2385-008—PT-2385-0091672665-69-8PT-2385-0101672665-55-2PT-2385-0115332-73-0PT-2385-0122004756-77-6PT-2385-0131672665-59-6API · PT-2385

Code	CAS No.	Intermediate
PT-2385-001	1073-72-9	4-(methylthio)phenol
PT-2385-002	67868-84-2	2-hydroxy-5-(methylthio)benzaldehyde
PT-2385-003	2033-24-1	2,2-dimethyl-1,3-dioxane-4,6-dione
PT-2385-004	2004756-76-5	6-(methylthio)-2-oxo-2H-chromene-3-carboxylic acid
PT-2385-005	1672665-65-4	3-(2-hydroxy-5-(methylthio)phenyl)propanoic acid
PT-2385-006	64248-63-1	3,5-difluorobenzonitrile
PT-2385-007	1672665-67-6	3-(2-(3-cyano-5-fluorophenoxy)-5-(methylthio)phenyl)propanoic acid
PT-2385-008	-	3-(2-(3-cyano-5-fluorophenoxy)-5-(methylthio)phenyl)propanoyl chloride
PT-2385-009	1672665-69-8	3-fluoro-5-((7-(methylthio)-1-oxo-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile
PT-2385-010	1672665-55-2 Available	3-fluoro-5-((7-(methylsulfonyl)-1-oxo-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile
PT-2385-011	5332-73-0	3-methoxypropan-1-amine
PT-2385-012	2004756-77-6	(E)-3-fluoro-5-((1-((3-methoxypropyl)imino)-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile
PT-2385-013	1672665-59-6	3-((2,2-difluoro-7-(methylsulfonyl)-1-oxo-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile

Frequently asked questions

What are the approved indications of PT-2385?

Approved indications include: von Hippel-Lindau syndrome, Sarcoma, Renal cell carcinoma, 肾肿瘤, Glioblastoma.

When does the PT-2385 patent expire?

No public expiry year is available for PT-2385 yet; this page updates once verified.

How many synthesis routes are recorded for PT-2385?

2 synthesis routes are recorded; the shortest is 6 steps with 2.15 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy PT-2385 intermediates?

1 intermediate CAS of PT-2385 are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for PT-2385 intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-10-09