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CAS 1001269-85-7
(5R,7R)-5-methyl-4-(piperazin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-7-ol dihydrochloride
Codes: IPAT-007
Application context (from source-drug indications)
Breast cancerIpatasertib三阴性乳腺癌IpatasertibCastration-resistant prostate cancerIpatasertibProstate cancerIpatasertibPeritoneal cancerIpatasertibOvarian cancerIpatasertib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ipatasertib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(4-chlorophenyl)acetyl chloride→(R)-4-benzyloxazolidin-2-one→(R)-4-benzyl-3-(2-(4-chlorophenyl)acetyl)oxazolidin-2-one→tert-butyl isopropyl(methoxymethyl)carbamate→tert-butyl ((S)-3-((R)-4-benzyl-2-oxooxazolidin-3-yl)-2-(4-chlorophenyl)-3-oxopropyl)(isopropyl)carbamate→(S)-3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-chlorophenyl)propanoic acid→(5R,7R)-5-methyl-4-(piperazin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-7-ol dihydrochloride→tert-butyl ((S)-2-(4-chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)(isopropyl)carbamate→(S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one dihydrochloride
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