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CAS 1074-82-4
1,3-Dihydro-1,3-dioxoisoindole potassium saltpotassium 1,3-dioxoisoindolin-2-ide
Codes: Tamsulosin Hydrochloride-063, MEMA-007, LEVO-011, DIFAM-010, Mosapride Citrate-023
Application context (from source-drug indications)
Erectile dysfunctionTadalafil/TamsulosinBenign prostatic hyperplasiaTadalafil/TamsulosinAlzheimer's diseaseMemantine Hydrochloride/Donepezil HydrochlorideLower urinary tract symptomsSolifenacin Succinate/Tamsulosin HydrochlorideBenign prostatic hyperplasiaSolifenacin Succinate/Tamsulosin HydrochlorideOveractive bladderSolifenacin Succinate/Tamsulosin HydrochlorideDrug-related adverse effects and reactionsSolifenacin Succinate/Tamsulosin HydrochlorideBladder neck obstructionSolifenacin Succinate/Tamsulosin HydrochlorideMajor depressive disorderLevomilnacipran HydrochlorideIschaemic strokeLevomilnacipran HydrochlorideDepressionLevomilnacipran HydrochlorideBenign prostatic hyperplasiaDutasteride/Tamsulosin HydrochlorideBenign prostatic hyperplasiaTamsulosin HydrochlorideUrinary tract infectionTamsulosin HydrochlorideUrinary retentionTamsulosin HydrochlorideInguinal herniaTamsulosin HydrochlorideVoiding dysfunctionTamsulosin HydrochlorideLower urinary tract symptomsTamsulosin HydrochlorideAlzheimer's diseaseMemantine HydrochlorideTraumatic brain injuryMemantine HydrochlorideTrichotillomaniaMemantine HydrochlorideSchizophreniaMemantine HydrochlorideLung cancerMemantine HydrochlorideSmall cell lung cancerMemantine HydrochlorideAtopic dermatitisDifamilastGastritisMosapride CitrateEnteral feeding intoleranceMosapride CitrateIrritable bowel syndromeMosapride CitrateDyspepsiaMosapride CitrateConstipationMosapride Citrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tadalafil/Tamsulosin | Tier C — Watch / trade | - |
| Memantine Hydrochloride/Donepezil Hydrochloride | Tier C — Watch / trade | - |
| Solifenacin Succinate/Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Levomilnacipran Hydrochloride | Tier C — Watch / trade | - |
| Dutasteride/Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Tamsulosin Hydrochloride | Tier C — Watch / trade | - |
| Memantine Hydrochloride | Tier B — Position early | - |
| Difamilast | Tier C — Watch / trade | - |
| Mosapride Citrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-Hydroxy-2-ethoxybenzene→1,2-Dichloroethane→1-(2-Chloroethoxy)-2-ethoxybenzene→1,3-Dihydro-1,3-dioxoisoindole potassium salt→2-[2-(2-Ethoxyphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione→2-(2-Ethoxyphenoxy)ethylamine
(1r,3R,5S,7r)-1-bromo-3,5-dimethyladamantane→potassium 1,3-dioxoisoindolin-2-ide→2-((1r,3R,5S,7r)-3,5-dimethyladamantan-1-yl)isoindoline-1,3-dione
Solifenacin Succinate/Tamsulosin HydrochlorideOptimised routesteps: 3total yield: 20g(Tamsulosin Hydrochloride-065)
1-Hydroxy-2-ethoxybenzene→1,2-Dichloroethane→1-(2-Chloroethoxy)-2-ethoxybenzene→1,3-Dihydro-1,3-dioxoisoindole potassium salt→2-[2-(2-Ethoxyphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione→2-(2-Ethoxyphenoxy)ethylamine
(R)-2-(chloromethyl)oxirane→2-phenylacetonitrile→(1S,2R)-2-(hydroxymethyl)-1-phenylcyclopropanecarbonitrile→(1S,2R)-2-(hydroxymethyl)-1-phenylcyclopropanecarboxylic acid→(1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one→(1S,2R)-N,N-diethyl-2-(hydroxymethyl)-1-phenylcyclopropanecarboxamide→(1S,2R)-2-(chloromethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide→potassium 1,3-dioxoisoindolin-2-ide→(1S,2R)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide
Dutasteride/Tamsulosin HydrochlorideOptimised routesteps: 3total yield: 20g(Tamsulosin Hydrochloride-065)
1-Hydroxy-2-ethoxybenzene→1,2-Dichloroethane→1-(2-Chloroethoxy)-2-ethoxybenzene→1,3-Dihydro-1,3-dioxoisoindole potassium salt→2-[2-(2-Ethoxyphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione→2-(2-Ethoxyphenoxy)ethylamine
1-Hydroxy-2-ethoxybenzene→1,2-Dichloroethane→1-(2-Chloroethoxy)-2-ethoxybenzene→1,3-Dihydro-1,3-dioxoisoindole potassium salt→2-[2-(2-Ethoxyphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione→2-(2-Ethoxyphenoxy)ethylamine
(1r,3R,5S,7r)-1-bromo-3,5-dimethyladamantane→potassium 1,3-dioxoisoindolin-2-ide→2-((1r,3R,5S,7r)-3,5-dimethyladamantan-1-yl)isoindoline-1,3-dione
ethyl 4-(benzyloxy)-3-hydroxybenzoate→4-(benzyloxy)-3-isopropoxybenzoic acid→4-(benzyloxy)-3-isopropoxybenzamide→ethyl 3-bromo-2-oxopropanoate→ethyl 2-(4-(benzyloxy)-3-isopropoxyphenyl)oxazole-4-carboxylate→ethyl 2-(4-hydroxy-3-isopropoxyphenyl)oxazole-4-carboxylate→ethyl 2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazole-4-carboxylate→(2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methanol→4-(bromomethyl)-2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazole→potassium 1,3-dioxoisoindolin-2-ide→2-((2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methyl)isoindoline-1,3-dione→(2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methanamine hydrochloride→2-ethoxybenzoic acid→N-((2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methyl)-2-ethoxybenzamide
[4-(4-Fluorobenzyl)-2-morpholinyl]methylamine→Sulfuric acid 1-[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine→Phosphoric acid 1-[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine→1-[4-[(4-Fluorophenyl)methyl]morpholin-2-yl]methanamine hydrogen chloride→2-Methylpropane-1,2,3-tricarboxylic acid 1-[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine→4-Fluorobenzaldehyde→2-Hydroxyethylamine→2-[(E)-[(4-Fluorophenyl)methylidene]amino]ethan-1-ol→2-[[(4-Fluorophenyl)methyl]amino]ethan-1-ol→2-[(Oxiran-2-yl)methyl]-1H-isoindole-1,3(2H)-dione→1,3-Dihydro-1,3-dioxoisoindole→1,3-Dihydro-1,3-dioxoisoindole potassium salt→(+/-)-Epichlorohydrin
[4-(4-Fluorobenzyl)-2-morpholinyl]methylamine→2-Hydroxyethylamine→2-[[(4-Fluorophenyl)methyl]amino]ethan-1-ol→1,3-Dihydro-1,3-dioxoisoindole potassium salt→Glycerol-alpha,gamma-dichlorohydrin→N-(3-Chloro-2-hydroxypropyl)-phthalimide→2-(3-[[(4-Fluorophenyl)methyl](2-hydroxyethyl)amino]-2-hydroxypropyl)-1H-isoindole-1,3(2H)-dione→2-[2-Hydroxy-3-[(2-hydroxyethyl)amino]propyl]-1H-isoindole-1,3(2H)-dione→Morpholin-2-ylmethanamine→alpha-Chloro-4-fluorotoluene
Intermediates available on this site
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