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CAS 1443983-86-5
2-[3-(Fluoromethyl)azetidin-1-yl]ethan-1-ol
Codes: (XIII)1078735-1-a, (VII)1078735-3-a
Application context (from source-drug indications)
Breast cancerImlunestrant TosylateMetastatic breast cancerImlunestrant TosylateMetastatic cancerImlunestrant TosylateOvarian cancerImlunestrant TosylateEndometrial cancerImlunestrant TosylateColorectal cancerImlunestrant Tosylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Imlunestrant Tosylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-Bromo-3-chloro-7-methoxyquinoline→4-Fluoranylbenzoyl chloride→(3-Chloro-7-methoxyquinolin-4-yl)(4-fluorophenyl)methanone→(3-Chloro-7-hydroxyquinolin-4-yl)(4-fluorophenyl)methanone→2-[3-(Fluoromethyl)azetidin-1-yl]ethan-1-ol hydrogen chloride→(3-Chloro-7-hydroxyquinolin-4-yl)(4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl)methanone→[2-Fluoro-4-(trifluoromethyl)phenyl]boronic acid→(4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]phenyl)[3-[2-fluoro-4-(trifluoromethyl)phenyl]-7-hydroxyquinolin-4-yl]methanone→4-[(4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]phenyl)(hydroxy)methyl]-3-[2-fluoro-4-(trifluoromethyl)phenyl]quinolin-7-ol→5-(4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]phenyl)-8-(trifluoromethyl)-5H-[1]benzopyrano[4,3-c]quinolin-2-ol→3-(Fluoromethyl)azetidine hydrogen chloride→1,4-Dioxane-2,5-diol→2-[3-(Fluoromethyl)azetidin-1-yl]ethan-1-ol
4-Bromo-3-chloro-7-methoxyquinoline→4-Fluoro-2,3,5,6-tetradeutero-benzoyl chloride→(3-Chloro-7-methoxyquinolin-4-yl)[4-fluoro-2,3,5,6-tetradeutero-phenyl]methanone→(3-Chloro-7-hydroxyquinolin-4-yl)[4-fluoro-2,3,5,6-tetradeutero-phenyl]methanone→[2-Fluoro-4-(trifluoromethyl)phenyl]boronic acid→[4-Fluoro-2,3,5,6-tetradeutero-phenyl][3-[2-fluoro-4-(trifluoromethyl)phenyl]-7-hydroxyquinolin-4-yl]methanone→2-[3-(Fluoromethyl)azetidin-1-yl]ethan-1-ol→[4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]-2,3,5,6-tetradeutero-phenyl][3-[2-fluoro-4-(trifluoromethyl)phenyl]-7-hydroxyquinolin-4-yl]methanone→4-[[4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]-2,3,5,6-tetradeutero-phenyl](hydroxy)methyl]-3-[2-fluoro-4-(trifluoromethyl)phenyl]quinolin-7-ol→(±)-5-[4-[2-[3-(Fluoromethyl)azetidin-1-yl]ethoxy]-2,3,5,6-tetradeutero-phenyl]-8-(trifluoromethyl)-5H-[1]benzopyrano[4,3-c]quinolin-2-ol
Intermediates available on this site
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