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CAS 2172654-35-0
(3-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-6-bromo-5-methylpyrazin-2-yl)methanol
Codes: RMC-4630-009
Application context (from source-drug indications)
Non-small cell lung cancerVociprotafibSolid tumourVociprotafibColorectal cancerVociprotafibPancreatic cancerVociprotafibMetastatic cancerVociprotafib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Vociprotafib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
propane-1,2-diamine→diethyl 2-oxomalonate→ethyl 3-hydroxy-5-methylpyrazine-2-carboxylate→ethyl 6-bromo-3-hydroxy-5-methylpyrazine-2-carboxylate→ethyl 6-bromo-3-chloro-5-methylpyrazine-2-carboxylate→tert-butyl (3S,4S)-4-(((R)-tert-butylsulfinyl)amino)-3-methyl-2-oxa-8-azaspiro[4.5]decane-8-carboxylate→(3S,4S)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine→ethyl 3-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-6-bromo-5-methylpyrazine-2-carboxylate→(3-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-6-bromo-5-methylpyrazin-2-yl)methanol→4-bromo-3-chloro-2-fluoropyridine→4-bromo-3-chloropyridin-2-amine→2-ethylhexyl 3-mercaptopropanoate→2-ethylhexyl 3-((2-amino-3-chloropyridin-4-yl)thio)propanoate→2-amino-3-chloropyridine-4-thiol
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