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CAS 2180923-73-1
Ethyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(piperazin-1 -yl)benzoate
Codes: (XVI)992511-1-b,(XVI)992511-1-c
Application context (from source-drug indications)
Chronic lymphocytic leukaemiaLisaftoclaxAcute promyelocytic leukaemiaLisaftoclaxMyelodysplastic syndromeLisaftoclaxAcute myeloid leukaemiaLisaftoclaxDiffuse large B-cell lymphomaLisaftoclaxSystemic lupus erythematosusLisaftoclax
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lisaftoclax | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-Nitro-4-[[(2S)-1,4-dioxan-2-yl]methylamino]benzenesulfonamide→7-(Chloromethyl)-6-(4-chlorophenyl)spiro[3.5]non-6-ene→Ethyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(piperazin-1 -yl)benzoate→Ethyl 4-(4-[[6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl]piperazin-1-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzoate→4-(4-[[6-(4-Chlorophenyl)spiro[3.5]non-6-en-7-yl]methyl]piperazin-1-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzoic acid
Ethyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(piperazin-1 -yl)benzoate→Ethyl 2,4-difluorobenzoate→1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol→Ethyl 2-((1H-pyrrolo[2,3-b]pyridin-5- yl)oxy)-4-fluorobenzoate→1-(1,1-Dimethylethoxycarbonyl)piperazine→tert-Butyl 4-[4-(ethoxycarbonyl)-3-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]phenyl]piperazine-1-carboxylate
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