CAS 229625-50-7

di-tert-butyl (chloromethyl) phosphate

Codes: FOSR-002, FOST-004

Application context (from source-drug indications)

Radiation injuryL-Arginine hydrochloride/L-Lysine hydrochlorideImmune thrombocytopenic purpuraFostamatinib disodium hexahydrateThrombocytopeniaFostamatinib disodium hexahydrateViral pneumoniaFostamatinib disodium hexahydratePneumoniaFostamatinib disodium hexahydrateCOVID-19Fostamatinib disodium hexahydrateSevere acute respiratory syndromeFostamatinib disodium hexahydrateOnychomycosisFosravuconazole L-Lysine EthanolateChagas diseaseFosravuconazole L-Lysine Ethanolate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
L-Arginine hydrochloride/L-Lysine hydrochloride	Tier C — Watch / trade	-
Fostamatinib disodium hexahydrate	Tier C — Watch / trade	-
Fosravuconazole L-Lysine Ethanolate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

L-Arginine hydrochloride/L-Lysine hydrochlorideOriginator routesteps: 2total yield: 1.5 g

4-(2-((2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile→di-tert-butyl (chloromethyl) phosphate→di-tert-butyl ((((2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl)oxy)methyl) phosphate

Fostamatinib disodium hexahydrateOriginator routesteps: 4total yield: 8.18

6-[(2-chloro-5-fluoropyrimidin-4-yl)amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one→3,4,5-trimethoxyaniline→6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one→di-tert-butyl (chloromethyl) phosphate→di-tert-butyl ((6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl) phosphate→(6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl dihydrogen phosphate

Fosravuconazole L-Lysine EthanolateOriginator routesteps: 2total yield: 1.5 g

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Qualified Partner — East China API Works	6-Amino-2,2-dimethyl-2H-pyrido[3,2-B][1,4]oxazin-3(4H)-one Pharmaceutical Intermediates	On request	On request	On request	—

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