Unibest
← Back to patent-cliff list

CAS 5470-11-1

Amino alcohol hydrochlorideHydroxylamine hydrochloric acid saltHydroxylamine hydrochlorideHydroxylammonium chloride

Codes: (II)638294-19-a, Tazobactam Sodium-072, (VIII)700647-1-a,(VIII)700647-1-d, (II)700647-2-a, Molnupiravir-024, (II)145089-25-a, Granisetron-016

Application context (from source-drug indications)

Systolic heart failureFinerenoneDiastolic heart failureFinerenoneHeart failureFinerenoneChronic renal impairmentFinerenoneDiabetic nephropathyFinerenoneType 2 diabetesFinerenoneIntra-abdominal infectionTazobactam Sodium/CeftolozaneVentilator-associated pneumoniaTazobactam Sodium/CeftolozaneUrinary tract infectionTazobactam Sodium/CeftolozaneCommunity-acquired bacterial pneumoniaTazobactam Sodium/CeftolozanePyelonephritisTazobactam Sodium/CeftolozaneHospital-acquired pneumoniaTazobactam Sodium/CeftolozaneBacterial infectionCeftazidime/Tazobactam SodiumRespiratory tract infectionCeftazidime/Tazobactam SodiumUrinary tract infectionCeftazidime/Tazobactam SodiumBacterial infectionTazobactam Sodium蠕形螨性睑缘炎Lotilaner螨虫感染Lotilaner莱姆病LotilanerRosaceaLotilaner睑板腺功能障碍LotilanerCOVID-19Molnupiravir呼吸道合胞体病毒感染MolnupiravirInfluenza virus infectionMolnupiravirRenal impairmentMolnupiravirHepatic function declineMolnupiravirAlzheimer's diseaseRivastigmine TartrateDementiaRivastigmine TartrateParkinson's diseaseRivastigmine Tartrate抗胆碱能综合征Rivastigmine Tartrate神经行为学表现Rivastigmine TartrateCognitive impairmentRivastigmine TartrateChemotherapy-induced nausea and vomitingGranisetronNauseaGranisetron呕吐Granisetron手术后恶心呕吐GranisetronPostoperative painGranisetronGastroparesisGranisetron

Source drugs (routes using this intermediate)

DrugTierExpiry
FinerenoneTier C — Watch / trade2030
Tazobactam Sodium/CeftolozaneTier C — Watch / trade-
Ceftazidime/Tazobactam SodiumTier C — Watch / trade-
Tazobactam SodiumTier C — Watch / trade-
LotilanerTier C — Watch / trade-
MolnupiravirTier B — Position early-
Rivastigmine TartrateTier B — Position early-
GranisetronTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

FinerenoneOptimised routesteps: 3total yield: /
(±)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide→Amino alcohol hydrochloride→5-Ethoxy-4-[4-[(hydroxyimino)methyl]-2-methoxyphenyl]-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide→(4S)-5-Ethoxy-4-[4-[(hydroxyimino)methyl]-2-methoxyphenyl]-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide
Tazobactam Sodium/CeftolozaneOptimised routesteps: 3total yield: 43.6g(Tazobactam Sodium-027)
Ceftazidime/Tazobactam SodiumOptimised routesteps: 3total yield: 43.6g(Tazobactam Sodium-027)
Tazobactam SodiumOptimised routesteps: 3total yield: 43.6g(Tazobactam Sodium-027)
LotilanerOptimised routesteps: 8total yield: /
4-Methylthiophene-2-carboxylic acid→N-Methoxy-N,4-dimethylthiophene-2-carboxamide→Bromo(methyl)magnesium→1-(4-Methylthiophen-2-yl)ethan-1-one→3-(5-Bromo-4-methylthiophen-2-yl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazole→1-(5-Bromo-4-methylthiophen-2-yl)ethan-1-one→2,2,2-Trifluoro-1-(3,4,5-trichlorophenyl)ethan-1-one→1-(5-Bromo-4-methylthiophen-2-yl)-4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-2-en-1-one→Amino alcohol hydrochloride→3-Methyl-5-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]thiophene-2-carboxylic acid→3-Methyl-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]thiophene-2-carboxylic acid→2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride→5-Bromo-1,2,3-trichlorobenzene→(3,4,5-Trichlorophenyl)magnesium bromide→2,2,2-Trifluoro-N,N-dimethylacetamide
LotilanerOptimised routesteps: 7total yield: /
1-(5-Bromo-4-methylthiophen-2-yl)ethan-1-one→2,2,2-Trifluoro-1-(3,4,5-trichlorophenyl)ethan-1-one→1-(5-Bromo-4-methylthiophen-2-yl)-4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-2-en-1-one→Amino alcohol hydrochloride→3-Methyl-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]thiophene-2-carboxylic acid→2-(5-Bromo-4-methylthiophen-2-yl)-2-methyl-1,3-dioxolane→3-Methyl-5-(2-methyl-1,3-dioxolan-2-yl)thiophene-2-carboxylic acid→Methyl 3-methyl-5-(2-methyl-1,3-dioxolan-2-yl)thiophene-2-carboxylate→Methyl 5-acetyl-3-methylthiophene-2-carboxylate→Methyl 3-methyl-5-[4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-2-enoyl]thiophene-2-carboxylate→Amine N-oxide→Methyl 3-methyl-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]thiophene-2-carboxylate→(5S)-3-(5-Bromo-4-methylthiophen-2-yl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazole
LotilanerOptimised routesteps: 5total yield: /
5-Formyl-3-methylthiophene-2-carboxylic acid→Amino alcohol hydrochloride→5-[(Hydroxyimino)methyl]-3-methylthiophene-2-carboxylic acid→2-Amino-N-(2,2,2-trifluoroethyl)acetamide→5-[(Hydroxyimino)methyl]-3-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]thiophene-2-carboxamide→5-Formyl-3-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]thiophene-2-carboxamide→N-Hydroxy-4-methyl-5-([2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]carbamoyl)thiophene-2-carboximidoyl chloride→4-Methyl-5-([2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]carbamoyl)thiophene-2-carbonitrile oxide→1,2,3-Trichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene→(±)-3-Methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-5-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]thiophene-2-carboxamide
MolnupiravirOptimised routesteps: 12total yield: /
Molnupiravir-012→Methyl 2,3-O-isopropylidene-beta-D-ribofuranoside→Methyl 5-O-benzoyl-2,3-O-(1-methylethylidene)-beta-D-ribofuranoside→1,2,3-Tri-O-acetyl-5-O-benzoyl-beta-D-ribofuranose→2-Methylpropionyl chloride→N-(2-Oxo-1,2-dihydropyrimidin-4-yl)acetamide→N-Acetyl-2',3'-di-O-acetyl-5'-O-benzoylcytidine→Cytosine-1-beta-D-ribofuranoside→Sulfuric acid 2',3'-O-(1-methylethylidene)cytidine→2',3'-O-(1-Methylethylidene)cytidine→2',3'-O-(1-Methylethylidene)-N-(2-methylpropanoyl)-5'-O-(2-methylpropanoyl)cytidine→Hydroxylamine→Hydroxylamine hydrochloride→Hydroxylamine sulfate→N-Hydroxy-2',3'-O-(1-methylethylidene)-5'-O-(2-methylpropanoyl)cytidine→2-Methylpropionic anhydride
MolnupiravirOptimised routesteps: 7total yield: 30.72g(Molnupiravir)
MolnupiravirOptimised routesteps: 7total yield: 1.65g(Molnupiravir)
1,2,3-Tri-O-acetyl-5-O-(triphenylmethyl)-D-ribofuranose→2',3'-Di-O-acetyluridine→2',3'-Di-O-acetyl-5'-O-(2-methylpropanoyl)uridine→1-[2,3-Di-O-acetyl-5-O-(2-methylpropanoyl)-beta-D-ribofuranosyl]-4-[[2,4,6-tri(propan-2-yl)benzene-1-sulfonyl]oxy]pyrimidin-2(1H)-one→Molnupiravir-052→2,4(1H,3H)-Pyrimidinedione→2-Methylpropionic anhydride→Hydroxylamine hydrochloride
Rivastigmine TartrateOptimised routesteps: 4total yield: /
1-Phenyl-1-propanone→Amino alcohol hydrochloride→N-[1-Phenylpropylidene]hydroxylamine→N-[1-Phenylprop-1-en-1-yl]acetamide→N-[(1R)-1-Phenylpropyl]acetamide→(R)-(+)-alpha-Ethylbenzylamine

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

SupplierProductPrice bandMOQLead timeQualificationsAction
Unibest Nantong cGMP Site4-Bromo-2-methoxybenzaldehyde
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Site4-formyl-3-methoxybenzonitrile
Pharmaceutical Intermediates
On requestOn requestOn request
—
Qualified Partner — East China API Works4-AMino-5-Methylpyridin-2-ol
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP Site2-chloro-5-methylpyridin-4-amine
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Site2-Cyanoethyl 3-oxobutanoate
Pharmaceutical Intermediates
On requestOn requestOn request
—
Qualified Partner — East China API Works2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP Site2-bromo-3-methyl-5-acetylthiophene
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Sitemethyl 5-acetyl-3-methylthiophene-2-carboxylate
Pharmaceutical Intermediates
On requestOn requestOn request
—
Qualified Partner — East China API Works5-acetyl-3-methyl-2-Thiophenecarboxylic acid
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Site((3aR,4R,6R,6aR)-6-(4-(hydroxyamino)-2-oxopyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like SiteBENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE]
Pharmaceutical Intermediates
On requestOn requestOn request
—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.