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CAS 638-07-3
Ethyl 4-chloro-3-oxobutanoate4-Chloro-3-oxobutyric acid ethyl esterEthyl 4-chloroacetoacetate
Codes: (I)109067-1-a, (I)109067-2-a, (I)109067-3-a, (III)109067-4-a, (IV)109067-5-a, (II)109067-8-a,(II)109067-8-b, (III)109067-10-a
Application context (from source-drug indications)
HypertensionOlmesartan Medoxomil/Amlodipine orotateEssential hypertensionValsartan/Amlodipine OrotateVariant anginaAmlodipine OrotateHypertensionAmlodipine OrotateIschaemic heart diseaseAmlodipine OrotateStable anginaAmlodipine OrotateHypertensionAmlodipine CamsylateHypertensionAmlodipine MaleateAngina pectorisAmlodipine MaleateChronic renal impairmentAmlodipine Maleate肾性高血压Amlodipine MaleateHeart diseaseAmlodipine Maleate血管疾病Amlodipine Maleate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Olmesartan Medoxomil/Amlodipine orotate | Tier C — Watch / trade | - |
| Valsartan/Amlodipine Orotate | Tier C — Watch / trade | - |
| Amlodipine Orotate | Tier C — Watch / trade | - |
| Amlodipine Camsylate | Tier C — Watch / trade | - |
| Amlodipine Maleate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Ethyl 4-chloro-3-oxobutanoate→Ethyl 4-[(4-methylbenzene-1-sulfonyl)oxy]-3-oxobutanoate→N-(2-Hydroxyethyl)phthalimide→Ethyl 4-(2-phthalimidoethoxy)acetoacetate→Ethyl (2Z)-3-amino-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]but-2-enoate→Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate→3-Ethyl 5-methyl (4RS)-4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Diethoxyacetic acid ethyl ester→2,2-Diethoxyethanol→4-Chloro-3-oxobutyric acid ethyl ester→ethyl 4-(2,2-diethoxyethoxy)-3-oxobutanoate→2-Chlorobenzaldehyde→ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-4-(2,2-dimethoxyethoxy)-3-oxobutanoate→Methyl 3-amino-2-butenoate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(2,2-dimethoxyethoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→ethyl (2E)-3-amino-4-(2,2-diethoxyethoxy)but-2-enoate→Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate
2-Aminoethanol→(2-chloro-1,1-diphenylethyl)benzene→2-[(triphenylmethyl)amino]ethan-1-ol→Ethyl 4-chloroacetoacetate→ethyl 3-oxo-4-{2-[(triphenylmethyl)amino]ethoxy}butanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-({2-[(triphenylmethyl)amino]ethoxy}methyl)-1,4-dihydropyridine-3,5-dicarboxylate
[5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methanol→4-Chloro-3-oxobutyric acid ethyl ester→ethyl 4-({5-[(4-ethoxy-2,4-dioxobutoxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methoxy)-3-oxobutanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-({[5-({[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(4-{[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}-2,3-dihydroxybutoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[(2-oxoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
4-Chloro-3-oxobutyric acid ethyl ester→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[(2-oxoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methanol→ethyl 4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]-3-oxobutanoate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(2,3-dihydroxypropoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Ethyl 4-chloro-3-oxobutanoate→Ethyl 4-[(4-methylbenzene-1-sulfonyl)oxy]-3-oxobutanoate→N-(2-Hydroxyethyl)phthalimide→Ethyl 4-(2-phthalimidoethoxy)acetoacetate→Ethyl (2Z)-3-amino-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]but-2-enoate→Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate→3-Ethyl 5-methyl (4RS)-4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Diethoxyacetic acid ethyl ester→2,2-Diethoxyethanol→4-Chloro-3-oxobutyric acid ethyl ester→ethyl 4-(2,2-diethoxyethoxy)-3-oxobutanoate→2-Chlorobenzaldehyde→ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-4-(2,2-dimethoxyethoxy)-3-oxobutanoate→Methyl 3-amino-2-butenoate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(2,2-dimethoxyethoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→ethyl (2E)-3-amino-4-(2,2-diethoxyethoxy)but-2-enoate→Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate
2-Aminoethanol→(2-chloro-1,1-diphenylethyl)benzene→2-[(triphenylmethyl)amino]ethan-1-ol→Ethyl 4-chloroacetoacetate→ethyl 3-oxo-4-{2-[(triphenylmethyl)amino]ethoxy}butanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-({2-[(triphenylmethyl)amino]ethoxy}methyl)-1,4-dihydropyridine-3,5-dicarboxylate
[5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methanol→4-Chloro-3-oxobutyric acid ethyl ester→ethyl 4-({5-[(4-ethoxy-2,4-dioxobutoxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methoxy)-3-oxobutanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-({[5-({[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(4-{[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}-2,3-dihydroxybutoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[(2-oxoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
4-Chloro-3-oxobutyric acid ethyl ester→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[(2-oxoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methanol→ethyl 4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]-3-oxobutanoate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(2,3-dihydroxypropoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Ethyl 4-chloro-3-oxobutanoate→Ethyl 4-[(4-methylbenzene-1-sulfonyl)oxy]-3-oxobutanoate→N-(2-Hydroxyethyl)phthalimide→Ethyl 4-(2-phthalimidoethoxy)acetoacetate→Ethyl (2Z)-3-amino-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]but-2-enoate→Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate→3-Ethyl 5-methyl (4RS)-4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Diethoxyacetic acid ethyl ester→2,2-Diethoxyethanol→4-Chloro-3-oxobutyric acid ethyl ester→ethyl 4-(2,2-diethoxyethoxy)-3-oxobutanoate→2-Chlorobenzaldehyde→ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-4-(2,2-dimethoxyethoxy)-3-oxobutanoate→Methyl 3-amino-2-butenoate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(2,2-dimethoxyethoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→ethyl (2E)-3-amino-4-(2,2-diethoxyethoxy)but-2-enoate→Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate
2-Aminoethanol→(2-chloro-1,1-diphenylethyl)benzene→2-[(triphenylmethyl)amino]ethan-1-ol→Ethyl 4-chloroacetoacetate→ethyl 3-oxo-4-{2-[(triphenylmethyl)amino]ethoxy}butanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-({2-[(triphenylmethyl)amino]ethoxy}methyl)-1,4-dihydropyridine-3,5-dicarboxylate
[5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methanol→4-Chloro-3-oxobutyric acid ethyl ester→ethyl 4-({5-[(4-ethoxy-2,4-dioxobutoxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methoxy)-3-oxobutanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-({[5-({[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(4-{[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}-2,3-dihydroxybutoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[(2-oxoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
4-Chloro-3-oxobutyric acid ethyl ester→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[(2-oxoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methanol→ethyl 4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]-3-oxobutanoate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(2,3-dihydroxypropoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Ethyl 4-chloro-3-oxobutanoate→Ethyl 4-[(4-methylbenzene-1-sulfonyl)oxy]-3-oxobutanoate→N-(2-Hydroxyethyl)phthalimide→Ethyl 4-(2-phthalimidoethoxy)acetoacetate→Ethyl (2Z)-3-amino-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]but-2-enoate→Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate→3-Ethyl 5-methyl (4RS)-4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Diethoxyacetic acid ethyl ester→2,2-Diethoxyethanol→4-Chloro-3-oxobutyric acid ethyl ester→ethyl 4-(2,2-diethoxyethoxy)-3-oxobutanoate→2-Chlorobenzaldehyde→ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-4-(2,2-dimethoxyethoxy)-3-oxobutanoate→Methyl 3-amino-2-butenoate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(2,2-dimethoxyethoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→ethyl (2E)-3-amino-4-(2,2-diethoxyethoxy)but-2-enoate→Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate
2-Aminoethanol→(2-chloro-1,1-diphenylethyl)benzene→2-[(triphenylmethyl)amino]ethan-1-ol→Ethyl 4-chloroacetoacetate→ethyl 3-oxo-4-{2-[(triphenylmethyl)amino]ethoxy}butanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-({2-[(triphenylmethyl)amino]ethoxy}methyl)-1,4-dihydropyridine-3,5-dicarboxylate
[5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methanol→4-Chloro-3-oxobutyric acid ethyl ester→ethyl 4-({5-[(4-ethoxy-2,4-dioxobutoxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methoxy)-3-oxobutanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-({[5-({[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(4-{[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}-2,3-dihydroxybutoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[(2-oxoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
4-Chloro-3-oxobutyric acid ethyl ester→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[(2-oxoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methanol→ethyl 4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]-3-oxobutanoate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(2,3-dihydroxypropoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
2-Aminoethyl alcohol→2-Chloroethanol→2-(2-Hydroxyethyl)-1H-isoindole-1,3(2H)-dione→Ethyl 4-chloro-3-oxobutanoate→Ethyl 4-bromoacetoacetate→Ethyl 4-(2-phthalimidoethoxy)acetoacetate→2-Chlorobenzaldehyde→2-(2-Chlorobenzylidene)-4-(2-phthalimidoethoxy)acetoacetic acid ethyl ester→3-Amino-2-butenoic acid methyl ester→3-Ethyl 5-methyl (4RS)-4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
2-Aminoethyl alcohol→2-Chloroethanol→2-(2-Hydroxyethyl)-1H-isoindole-1,3(2H)-dione→Ethyl 4-chloro-3-oxobutanoate→Ethyl 4-bromoacetoacetate→Ethyl 4-(2-phthalimidoethoxy)acetoacetate→2-Chlorobenzaldehyde→2-(2-Chlorobenzylidene)-4-(2-phthalimidoethoxy)acetoacetic acid ethyl ester→3-Amino-2-butenoic acid methyl ester→3-Ethyl 5-methyl (4RS)-4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
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