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CAS 73183-34-3
4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)
Codes: RUXO-023, ABEM-006, ENCO-023, TELM-024, ELBA-009, DASA-016, VISM-012, CRIT-011, RISD-006, RAVI-011
Application context (from source-drug indications)
Atopic dermatitisRuxolitinib PhosphateVitiligoRuxolitinib PhosphateGraft-versus-host diseaseRuxolitinib PhosphateMyelofibrosisRuxolitinib PhosphatePolycythaemia veraRuxolitinib PhosphateBreast cancerAbemaciclibNon-small cell lung cancerEncorafenibColorectal cancerEncorafenibThyroid cancerEncorafenibMelanomaEncorafenibHypertensionTelmisartan/Amlodipine Besylate/HydrochlorothiazideHepatitis CElbasvirChronic hepatitis CElbasvirHepatic function declineElbasvirRenal impairmentElbasvirViral hepatitisElbasvirChronic hepatitis CDasabuvir Sodium HydrateHepatitis CDasabuvir Sodium HydrateDecompensated cirrhosisDasabuvir Sodium HydrateRenal impairmentDasabuvir Sodium HydrateFibrosisDasabuvir Sodium HydrateEnd-stage renal diseaseDasabuvir Sodium HydrateHypertensionRosuvastatin Calcium/TelmisartanHyperlipidaemiaRosuvastatin Calcium/TelmisartanBasal cell carcinomaVismodegibMultiple myelomaVismodegibLymphomaVismodegibSolid tumourVismodegibHaematological malignancyVismodegibMesenchymal chondrosarcomaVismodegibPrimary cutaneous anaplastic large cell lymphomaCrizotinibAnaplastic large cell lymphomaCrizotinibNon-small cell lung cancerCrizotinibSchwannomaCrizotinibNeurofibromatosis type IICrizotinibMultiple myelomaCrizotinibHypertensionAmlodipine Besylate/TelmisartanHypertensionTelmisartanBreast cancerTelmisartanCardiomyopathyTelmisartanAlzheimer's diseaseTelmisartanRisk-reduction measureTelmisartanMyocardial infarctionTelmisartanSpinal muscular atrophyRisdiplamHepatitis CRavidasvir HydrochlorideViral infectionRavidasvir HydrochlorideChronic hepatitis CRavidasvir Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ruxolitinib Phosphate | Tier A — Act now | 2028 |
| Abemaciclib | Tier A — Act now | 2029 |
| Encorafenib | Tier C — Watch / trade | 2030 |
| Telmisartan/Amlodipine Besylate/Hydrochlorothiazide | Tier C — Watch / trade | - |
| Elbasvir | Tier C — Watch / trade | - |
| Dasabuvir Sodium Hydrate | Tier C — Watch / trade | - |
| Rosuvastatin Calcium/Telmisartan | Tier C — Watch / trade | - |
| Vismodegib | Tier C — Watch / trade | - |
| Crizotinib | Tier C — Watch / trade | - |
| Amlodipine Besylate/Telmisartan | Tier C — Watch / trade | - |
| Telmisartan | Tier B — Position early | - |
| Risdiplam | Tier B — Position early | - |
| Ravidasvir Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-chloro-7H-pyrrolo[2,3-d]pyrimidine→(E)-3-cyclopentylacrylaldehyde→4-bromo-1H-pyrazole→(R)-3-(4-bromo-1H-pyrazol-1-yl)-3-cyclopentylpropanal→(R)-3-(4-bromo-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→(R)-3-cyclopentyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanenitrile
propan-2-amine→N-isopropylacetamide→4-bromo-2,6-difluoroaniline→(E)-N'-(4-bromo-2,6-difluorophenyl)-N-isopropylacetimidamide→6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole→2,4-dichloro-5-fluoropyrimidine→6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole→5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-amine→1-ethylpiperazine→6-bromonicotinaldehyde→1-((6-bromopyridin-3-yl)methyl)-4-ethylpiperazine
benzaldehyde→isopropylhydrazine hydrochloride→(E)-1-benzylidene-2-isopropylhydrazine→2-(ethoxymethylene)malononitrile→(E)-2-((2-benzylidene-1-isopropylhydrazinyl)methylene)malononitrile→3-amino-1-isopropyl-1H-pyrazole-4-carbonitrile→1-(3-amino-1-isopropyl-1H-pyrazol-4-yl)ethan-1-one→1-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)ethan-1-one→(Z)-3-(dimethylamino)-1-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)prop-2-en-1-one→guanidine hydrochloride→4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-amine→4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ol→2-chloro-4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidine→methyl (S)-(1-aminopropan-2-yl)carbamate hydrochloride→methyl (S)-(1-((4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate→tert-butyl (5-chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate→methyl (S)-(1-((4-(3-(3-((tert-butoxycarbonyl)amino)-5-chloro-2-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate→methyl (S)-(1-((4-(3-(3-amino-5-chloro-2-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate→methyl (S)-(1-((4-(3-(5-chloro-2-fluoro-3-(N-(methylsulfonyl)methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate→2-bromo-4-chloro-1-fluorobenzene→3-bromo-5-chloro-2-fluorobenzoic acid→tert-butyl (3-bromo-5-chloro-2-fluorophenyl)carbamate→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)
methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→4-bromo-2-methyl-6-nitroaniline→butyraldehyde→6-bromo-4-methyl-2-propyl-1H-benzo[d]imidazole→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→TELM-025→TELM-026→2-bromo-1-methyl-1H-benzo[d]imidazole
3-bromophenol→3-bromophenyl acetate→1-(4-bromo-2-hydroxyphenyl)ethan-1-one→(4-bromophenyl)hydrazine→(E)-5-bromo-2-(1-(2-(4-bromophenyl)hydrazineylidene)ethyl)phenol→5-bromo-2-(5-bromo-1H-indol-2-yl)phenol→(dibromomethyl)benzene→3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→6-phenyl-3,10-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indole→tert-butyl (S)-2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylate→di-tert-butyl 2,2'-((6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole-3,10-diyl)bis(1H-imidazole-4,2-diyl))(2S,2'S)-bis(pyrrolidine-1-carboxylate)→(S)-6-phenyl-3,10-bis(2-((S)-pyrrolidin-2-yl)-1H-imidazol-4-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indole→(methoxycarbonyl)-D-valine
4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→2-(tert-butyl)phenol→2-(tert-butyl)-4-nitrophenol→2-bromo-6-(tert-butyl)-4-nitrophenol→1-bromo-3-(tert-butyl)-2-methoxy-5-nitrobenzene→3-bromo-5-(tert-butyl)-4-methoxyaniline→tert-butyl (3-bromo-5-(tert-butyl)-4-methoxyphenyl)carbamate→N-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-yl)methanesulfonamide→tert-butyl (3-(tert-butyl)-4-methoxy-5-(6-(methylsulfonamido)naphthalen-2-yl)phenyl)carbamate→N-(6-(5-amino-3-(tert-butyl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide→(E)-3-methoxyacryloyl isocyanate→(E)-N-((3-(tert-butyl)-4-methoxy-5-(6-(methylsulfonamido)naphthalen-2-yl)phenyl)carbamoyl)-3-methoxyacrylamide→methyl 6-bromo-2-naphthoate→6-bromo-2-naphthoic acid→6-bromonaphthalen-2-amine→N-(6-bromonaphthalen-2-yl)methanesulfonamide
methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→4-bromo-2-methyl-6-nitroaniline→butyraldehyde→6-bromo-4-methyl-2-propyl-1H-benzo[d]imidazole→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→TELM-025→TELM-026→2-bromo-1-methyl-1H-benzo[d]imidazole
2-chloro-4-(methylsulfonyl)benzoyl chloride→4-chlorobenzoic acid→4-chloro-3-iodobenzoic acid→tert-butyl (4-chloro-3-iodophenyl)carbamate→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→tert-butyl (4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate→2-bromopyridine→tert-butyl (4-chloro-3-(pyridin-2-yl)phenyl)carbamate→4-chloro-3-(pyridin-2-yl)aniline
1-(2,6-dichloro-3-fluorophenyl)ethan-1-one→1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol→1-(2,6-dichloro-3-fluorophenyl)ethyl acetate→(S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate→(S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol→2-nitropyridin-3-ol→(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine→(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine→(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine→CRIT-010→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→CRIT-012→(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine→tert-butyl 4-(4-bromo-1H-pyrazol-1-yl)piperidine-1-carboxylate→tert-butyl (R)-4-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→tert-butyl (R)-4-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate→tert-butyl 4-hydroxypiperidine-1-carboxylate→tert-butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate→4-iodo-1H-pyrazole→tert-butyl 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate→tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→4-bromo-2-methyl-6-nitroaniline→butyraldehyde→6-bromo-4-methyl-2-propyl-1H-benzo[d]imidazole→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→TELM-025→TELM-026→2-bromo-1-methyl-1H-benzo[d]imidazole
methyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→4-bromo-2-methyl-6-nitroaniline→butyraldehyde→6-bromo-4-methyl-2-propyl-1H-benzo[d]imidazole→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→TELM-025→TELM-026→2-bromo-1-methyl-1H-benzo[d]imidazole
3,6-dichloro-4-methylpyridazine→6-chloro-5-methylpyridazin-3-amine→6-chloro-4-methylpyridazin-3-amine→1-bromo-2,2-dimethoxypropane→6-chloro-2,8-dimethylimidazo[1,2-b]pyridazine→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→2,8-dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine→2-chloro-7-fluoro-4H-pyrido[1,2-a]pyrimidin-4-one→2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-7-fluoro-4H-pyrido[1,2-a]pyrimidin-4-one→4,7-diazaspiro[2.5]octane hydrogen chloride→5-fluoropyridin-2-amine→dimethyl malonate→7-fluoro-2-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one
6-bromo-2-naphthoic acid→RAVI-002→RAVI-003→RAVI-004→(S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid→RAVI-006→RAVI-007→RAVI-008→(methoxycarbonyl)-D-valine→RAVI-010→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→RAVI-012→RAVI-013→4-bromobenzene-1,2-diamine→RAVI-015→RAVI-016
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)- Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 2,4-Dichloro-5-fluoropyrimidine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H- pyrazol-1-yl]piperidine-1-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | [5-Bromo-3-[(1R)-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin -2- yl]amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 2-amino-5-bromopyridin-3-ol Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 7-fluoro-2-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 4-Boc-4,7-diazaspiro[2.5]octane Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 2,8-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | -CYCLOPENTYLACRYLONITRILE Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | Cyclopentanecarbaldehyde Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 4-Chloropyrrolo[2,3-d]pyrimidine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 4-(1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | (3R)-3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | (S)-3-cyclopentyl-3-hydrazinylpropanenitrile L-tartaric acid salt dihydrate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 2-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetic acid Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 4-methyl-7H-pyrrolo[2,3-d]pyrimidine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | (4-(1-(2-Cyano-1-cyclopentylethyl)-1h-pyrazol-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 4-CHLORO-7-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-7H-PYRROLO[2,3-D]PYRIMIDINE Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 1H-Pyrazole-1-propanamide, 4-bromo-β-cyclopentyl-, (βR)- Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | (R)-3-(4-broMo-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | (R)-3-cyclopentyl-3-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanenitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 3-Cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate Pharmaceutical Intermediates | On request | On request | On request | — |
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